Serum Uric Acid and Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke
- PDF / 359,609 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 67 Downloads / 195 Views
Serum Uric Acid and Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke Quhong Song 1
&
Yanan Wang 1 & Yajun Cheng 1 & Junfeng Liu 1 & Chenchen Wei 1 & Ming Liu 1
Received: 25 July 2019 / Accepted: 27 August 2019 # Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Uric acid (UA) is an antioxidant with neuroprotective effects in experimental stroke models. Whether serum UA plays a role in hemorrhagic transformation (HT) remains unclear. We aimed to explore the association between serum UA and HT in patients with acute ischemic stroke (AIS). AIS patients within 7 days after stroke onset were consecutively enrolled between January 2016 and October 2017. Patients were categorized into three groups according to serum UA tertiles by sex. HT was detected by followup CT or MRI within 7 days after admission. The multivariate logistic analysis was performed to assess the association of serum UA with HT. We included 1230 patients (mean age 64.1 years, 63.5% males) and 133 (10.8%) patients experienced HT. After adjusting confounders, patients in the second and third UA tertiles showed a significant decrease in HT compared with those in the lowest tertile (OR 0.432, 95% CI 0.266–0.702; OR 0.033, 95% CI 0.013–0.086, respectively). Similar results were observed for sex-based subgroups. Males with higher UA had lower risk of HT compared with the lowest UA tertile (OR 0.332, 95% CI 0.170–0.651; OR 0.008, 95% CI 0.001–0.070, respectively). In females, the highest UA tertile was inversely associated with HT (OR 0.148, 95% CI 0.058–0.376). Multiple-adjusted spline regression analyses further confirmed the dose-response relationship between UA levels and HT. Higher serum UA is independently associated with lower HT following stroke. More studies are needed to elucidate the potential neuroprotective mechanism of serum UA and its link to HT. Keywords Serum uric acid . Hemorrhagic transformation . Acute ischemic stroke . Outcome
Introduction Hemorrhagic transformation (HT) is a common complication of acute ischemic stroke (AIS) (Jickling et al. 2014; Wu et al. 2019). It occurs in 10–40% of ischemic stroke patients (Jickling et al. 2014), and the occurrence of HT may discontinue or delay the treatment schemes such as the administration of antiplatelet and anticoagulant. Moreover, HT has been found to correlate with poor outcomes of ischemic stroke (Paciaroni et al. 2008; Park et al. 2012; Rao et al. 2014). Therefore, it is necessary to explore and identify the key Quhong Song and Yanan Wang contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12031-019-01404-x) contains supplementary material, which is available to authorized users. * Ming Liu [email protected] 1
Center of Cerebrovascular Disease, Department of Neurology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu 610041, Sichuan, China
factors of HT, which may help clinicians evaluate the risk of HT more accurately, design treatme
Data Loading...
