Lower uric acid level may be associated with hemorrhagic transformation but not functional outcomes in patients with ant
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ORIGINAL ARTICLE
Lower uric acid level may be associated with hemorrhagic transformation but not functional outcomes in patients with anterior circulation acute ischemic stroke undergoing endovascular thrombectomy Zhongyun Chen 1 & Hongbo Chen 2 & Yingbo Zhang 3 & Yanbo He 4 & Yingying Su 1 Received: 29 April 2020 / Accepted: 5 July 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract To determine the correlation of uric acid (UA) with hemorrhagic transformation (HT) and poor short-term functional outcomes in anterior circulation acute ischemic stroke (AIS) patients after endovascular thrombectomy (EVT). A retrospective analysis was conducted for anterior circulation AIS patients who underwent EVT at our hospital from 2015 to 2019. HT within 72 h was documented according to the European Cooperative Acute Stroke Study II Classification. Baseline demographic, clinical and laboratory data were compared between the HT and non-HT groups, and between patients with favorable and unfavorable outcomes on 90-day. A total of 247 AIS patients were enrolled, of which 92 (37.2%) and 85 (34.4%) experienced HT and had favorable functional outcomes at 3 months respectively. Patients with HT had significantly lower UA levels compared to those without HT (322.60 ± 94.49 vs. 350.25 ± 99.28 μmol /L, P = 0.032). In contrast, UA levels were similar in patients with good or poor outcomes (345.67 ± 103.55 vs. 336.95 ± 95.5 μmol /L, P = 0.509). Compared to the patients with UA levels in the first quartile, those in the fourth quartile were at a higher risk of HT in univariate logistic regression analysis (OR = 0.383, 95% CI = 0.173–0.848, P = 0.018). The association remained significant after multivariable adjustment for potential confounders. A lower UA level is an independent risk factor of HT post-EVT in anterior circulation AIS patients, but is not associated with the short-term functional outcomes. Keywords Uric acid . Hemorrhagic transformation . Prognosis . Ischemic stroke . Endovascular thrombectomy
Abbreviations ACA anterior cerebral artery ASPECTS alberta stroke program early CT score BMI body mass index DBP diastolic blood pressure eGFR estimated glomerular filtration rate * Yingying Su [email protected] 1
Department of Neurology, Xuanwu Hospital, Capital Medical University, No.45, ChangchunStreet, Beijing 100053, China
2
Department of Neurology, Liangxiang Hospital of Beijing Fangshan District, No. 45 Gongchen North Street, Gongchen Street Office, Fangshan District, Beijing 102246, China
3
Department of Neurology, Beijing Tsinghua Changgung Hospital affiliated to Tsinghua University, No.168, Litang road, Changping district, Beijing 102200, China
4
Department of Neurology, The Beijing Moslem People Hospital, No. 11. Youanmennei Street, Xicheng District, Beijing 100054, China
HDL-C HT ICA LAA LDL-C MCA mTICI NIHSS SBP UA WBC
high density liptein cholesterol hemorrhagic transformation internal carotid artery Large-Artery Atherosclerosis low density liptein cholesterol middle cerebral a
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