Severity of heart failure and health-related quality of life in beta-thalassemia patients: a cross-sectional study
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ORIGINAL ARTICLE
Severity of heart failure and health-related quality of life in beta-thalassemia patients: a cross-sectional study Yannis Dimitroglou 1,2,5 & Fotios Anagnostopoulos 2,3 & Constantina Aggeli 1 & Sophia Delicou 4 & Aikaterini Xydaki 4 & Dimitrios Patsourakos 1 & Dimitris Tousoulis 1 Received: 25 September 2019 / Accepted: 10 April 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Cardiovascular complications account for a substantial increase in morbidity and mortality in beta-thalassemia patients. Many patients have structural heart disease, and some of them present with symptomatic heart failure (HF). Quality of life (QOL) of beta-thalassemia patients is lower than that of the general population. The aim of our study was to explore the relationship between HF stages and QOL in beta-thalassemia patients. Seventy-three consecutive adult beta-thalassemia patients took part in this cross-sectional study. Stages of HF, classified with increasing severity as A, B, and C, were determined based on ACC/AHA guidelines. QOL was assessed using the SF-36 questionnaire. Fifteen patients had stage C HF, twenty-eight had stage B HF, and the remaining were considered stage A patients, as beta thalassemia is a predisposing factor for HF. All QOL domains except for bodily pain were significantly lower in stage C patients than in stage A patients. Stage C patients had significantly lower QOL scores for physical functioning, role physical, and social functioning domains than stage B patients. Stage B patients’ QOL differed from stage A patients only in the vitality domain. In the multiple regression analysis which took several demographic and clinical factors into account, stage of HF was the most important factor associated with QOL, and negatively and significantly related to five QOL domains, namely physical functioning, role physical, general health, social functioning, and vitality. In conclusion, QOL is negatively affected by the severity of heart failure in beta-thalassemia patients. Keywords Heart failure . Beta thalassemia . Iron overload . Health-related quality of life . SF-36
Introduction The authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation. The online version of this article(https://doi.org/10.1007/s00277-02004032-3) contains supplementarymaterial, which is available to authorized users. * Yannis Dimitroglou [email protected] 1
First Department of Cardiology, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece
2
School of Social Sciences, Hellenic Open University, Patras, Greece
3
Panteion University of Social and Political Sciences, Kallithea, Athens, Greece
4
Thalassemia and Sickle Cell Unit, Hippokration General Hospital, Athens, Greece
5
Present address: Palaio Faliro, 175 64 Athens, Greece
Beta thalassemia is an inherited blood disorder that can be caused by the absence or insufficient synthesis of the betaglobin
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