Signaling in the Heart
Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimu
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Signaling in the Heart By
José Marín-García, M.D. Director, The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA
With contributions by Alexander Akhmedov, Ph.D. and Vitalyi Rybin, Ph.D. Senior Research Scientist, The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA
José Marín-García, M.D. Director, The Molecular Cardiology and Neuromuscular Institute Raritan Avenue 75 08904 Highland Park NJ, USA [email protected]
ISBN 978-1-4419-9460-8 e-ISBN 978-1-4419-9461-5 DOI 10.1007/978-1-4419-9461-5 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011928241 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
To my wife Danièle and daughter Mélanie with love
ART WORKS for ‘Signaling in the Heart’
Danièle M. Marin ' Signaling pathway #1' Oil painting
Danièle M. Marin 'Signaling pathway #2' Cast Acrylic Print
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Danièle M. Marin ‘Signaling pathway #3’ Mixed Media Painting
Danièle M. Marin 'Signaling pathway #4' Oil painting
The molecular phenomena of signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. These four paintings, the work of the author’s wife, Danièle M. Marin were inspired by some of these signaling pathways. Artwork #1 Artwork #2 Artwork #3 Artwork #4
Mitochondria: a receiver and integrator of signals. Cell cycle signaling. Rapid signaling pathways. Growth factors signaling pathways. vii
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Preface
Signal transduction is at the core of most biological processes and represents a critical area of research. Signal transduction is extremely important not only to molecular biology research, but also to clinical medicine in general since many diseases, such as diabetes, cardiovascular diseases, autoimmunity, and cancer, arise from defects in signal t
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