Silk peptide treatment can improve the exercise performance of mice
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RESEARCH ARTICLE
Open Access
Silk peptide treatment can improve the exercise performance of mice Jisu Kim, Hyejung Hwang, Jonghoon Park, Hea-Yeon Yun, Heajung Suh and Kiwon Lim*
Abstract Background: We previously reported that silk peptide (SP) treatment led to increased resting fat oxidation in exercised mice. However, it was not known whether SP treatment could effectively increase exercise capacity. Accordingly, this study aimed to examine whether SP treatment affected energy metabolism during exercise in addition to exercise performance. Methods: We randomized 36 7-week-old male ICR mice into 2 groups: the control (n = 18) and SP (n = 18) groups. All mice were trained by treadmill running 5 times per week for 2 weeks. SP was dissolved in distilled water and daily 800-mg/kg body weight doses before the running exercise were oral administered intraperitoneally to the SP _ 2 max was measured before and after the 2 weeks training period. We also assessed energy group for 2 weeks. VO metabolism during exercise for 1 h after the 2 week training period. In addition to blood samples, liver glycogen and gastrocnemius-white and gastrocnemius-red muscle was obtained at the following 3 time points: at rest, immediately after exercise, and 1-hour post exercise. _ 2 max after 2 weeks of training was significantly increased (8%) in the SP group compared to the Results: The VO baseline; a similar result was not observed in the CON group. The sum of fat oxidation during a 1-h period tended to be 13% higher in the SP group than in the CON group (P < 0.077). In particular, the sum of fat oxidation was significantly higher in the SP group during the initial 20-min phase than that in the CON group (P < 0.05). The glycogen concentration in the white gastrocnemius muscle did not differ between the groups either rest or after 1 h of exercise but was significantly higher in the SP group than in the CON group during the recovery period (1 h post-exercise completion). Conclusions: These results suggest that SP treatment can improve the exercise performance. Therefore, SP is considered to confer beneficial effects upon athletes, in whom exercise abilities are required. Keywords: Silk peptide, Exercise performance, Energy metabolism during exercise, Fat oxidation
Background The 3 key factors of athletic performance enhancement are training, nutrition, and rest [1]. Of these, the diet chosen by an athlete will affect his performance on and off the track through its effects on both fitness and health [2]. Therefore, many athletes have used dietary supplements to increase their exercise capacities [3-5]. However, many of these dietary supplements have added artificial chemical and overdoses have caused many side effects [6,7]. As a result, many researchers have been
investigating natural ergogenic foods that do not cause any side effects. Silk peptide (SP) has been ingested for many years in Asian countries [8]. SP comprises biopolymers from the cocoons produced by silkworms for protection from the environment during metamorphosis to the
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