Single NIR Laser-Activated Multifunctional Nanoparticles for Cascaded Photothermal and Oxygen-Independent Photodynamic T
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ARTICLE
Cite as Nano-Micro Lett. (2019) 11:68 Received: 31 May 2019 Accepted: 24 July 2019 © The Author(s) 2019
https://doi.org/10.1007/s40820-019-0298-5
Single NIR Laser‑Activated Multifunctional Nanoparticles for Cascaded Photothermal and Oxygen‑Independent Photodynamic Therapy Xiaomin Li1, Yang Liu1, Fei Fu2, Mingbo Cheng1, Yutong Liu1, Licheng Yu1, Wei Wang1, Yeda Wan2 *, Zhi Yuan1 * * Yeda Wan, [email protected]; Zhi Yuan, [email protected] Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, People’s Republic of China 2 Department of Radiology, Tianjin Hospital, Tianjin 300210, People’s Republic of China 1
HIGHLIGHTS • Bi2Se3@AIPH nanoparticles (NPs) can realize photothermal and photodynamic therapies in a cascading manner when exposed to “one” single NIR laser. • Hyperthermia produced by Bi2Se3 NPs under NIR laser irradiation cannot only be used for photothermal therapy, but also the “switch” for controlled release of AIPH and excitation of free radical at the tumor site. • Free radical produced by thermal-responsive decomposition of AIPH is oxygen-independent, which treats hypoxic tumor well and further enhances immune response.
ABSTRACT Inconvenient dual-laser irradiation and tumor hypoxic environment as well as limited judgment of treating region have impeded the develop-
808 nm laser
ment of combined photothermal and photodynamic therapies (PTT and PDT). Herein, Bi2Se3@AIPH nanoparticles (NPs) are facilely developed to overcome these problems. Through a one-step method, free radical generator (AIPH) and
Oxygen-independent PDT R·
(ii)
phase transition material (lauric acid, LA, 44–46 °C) are encapsulated in hollow bismuth selenide nanoparticles (Bi2Se3 NPs). Under a single 808-nm laser
irradiation at the tumor area, hyperthermia produced by Bi2Se3 not only directly
leads to cell death, but also promotes AIPH release by melting LA and triggers
Cell death
(i) Bi2Se3@AIPH NPs
PTT
(iii) Immune response (iii)
free radical generation, which could further eradicate tumor cells in hypoxic environments. Moreover, Bi2Se3 with high X-ray attenuation coefficient endows the
NPs with high computed tomography (CT) imaging capability, which is important for treating area determination. The results exhibit that B i2Se3@AIPH NPs
possesses 31.2% photothermal conversion efficiency for enhanced PTT, ideal free radical generation for oxygen-independent PDT, and 37.77 HU mL mg−1 X-ray attenuation coefficient for CT imaging with high quality. Most importantly, the tumor growth inhibition rate by
synergistic PTT, PDT, and following immunotherapy is 99.6%, and even one tumor disappears completely, which demonstrates excellent cascaded synergistic effect of Bi2Se3@AIPH NPs for the tumor therapy. KEYWORDS Bi2Se3; Free radical; Oxygen-independent; Photothermal; Photodynamic
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1 Introduction Photothera
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