Multifunctional Nanoparticles for Drug Delivery Applications Imaging
This book clearly demonstrates the progression of nanoparticle therapeutics from basic research to applications. Unlike other books covering nanoparticles used in medical applications, Multifunctional Nanoparticles for Drug Delivery Applica
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Series Editor David J. Lockwood
For further volumes: http://www.springer.com/series/6331
Sonke Svenson
•
Robert K. Prud’homme
Editors
Multifunctional Nanoparticles for Drug Delivery Applications Imaging, Targeting, and Delivery
Editors Sonke Svenson, Ph.D. Drug Delivery Solutions LLC Arlington, MA, USA
Robert K. Prud’homme, Ph.D. Department of Chemical and Biological Engineering Princeton University Princeton, NJ, USA
ISSN 1571-5744 ISBN 978-1-4614-2304-1 e-ISBN 978-1-4614-2305-8 DOI 10.1007/978-1-4614-2305-8 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2012930125 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
1
Introduction: Benefits and Challenges for Multifunctional Nanoparticles in Medicine .................................... Robert K. Prud’homme and Sonke Svenson
Part I 2
1
Targeting and Drug Delivery
Nanoparticles for Targeted and Temporally Controlled Drug Delivery ....................................................................... Archana Swami, Jinjun Shi, Suresh Gadde, Alexander R. Votruba, Nagesh Kolishetti, and Omid C. Farokhzad
9
3
Development and Application of Anticancer Nanomedicine .............. Rong Tong, Li Tang, and Jianjun Cheng
31
4
Macrophage-Targeted Nanoparticle Delivery Systems ....................... Shardool Jain and Mansoor Amiji
47
5
Paclitaxel-Triazine Dendrimer Constructs: Efficacy, Toxicity, and Characterization............................................................... Eric E. Simanek and Jongdoo Lim
Part II
85
Dual or Multiple Drug Delivery (Combination Therapy)
6
Versatile Fixed-Ratio Drug Combination Delivery Using Hydrophobic Prodrug Nanoparticles ......................................... 103 Barry D. Liboiron, Paul G. Tardi, and Lawrence D. Mayer
7
Polymeric Micelles for Multiple-Drug Delivery ................................... 133 Glen S. Kwon
v
Contents
vi
Part III
Targeting and Imaging
8
Multifunctional Nanoparticles for Target-Specific Imaging and Therapy ............................................................................. 155 Anita Gianella, Joanna C. Read, David P. Cormode, Zahi A. Fayad, and Willem J.M. Mulder
9
Polymer-Modified Nanoparticles as Targete
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