Sirtuins
The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age
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Riekelt H. Houtkooper Editor
Sirtuins
Proteins and Cell Regulation Volume 10
Series editors Professor A.J. Ridley Ludwig Institute for Cancer Research, and Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom Professor Jon Frampton Professor of Stem Cell Biology, Institute for Biomedical Research, Birmingham University Medical School, Division of Immunity and Infection, Birmingham, United Kingdom
Aims and Scope Our knowledge of the ways in which a cell communicates with its environment and how it responds to information received has reached a level of almost bewildering complexity. The large diagrams of cells to be found on the walls of many a biologist’s offi ce are usually adorned with parallel and interconnecting pathways linking the multitude of components and suggest a clear logic and understanding of the role played by each protein. Of course this two-dimensional, albeit often colourful representation takes no account of the three-dimensional structure of a cell, the nature of the external and internal milieu, the dynamics of changes in protein levels and interactions, or the variations between cells in different tissues. Each book in this series, entitled “Proteins and Cell Regulation”, will seek to explore specific protein families or categories of proteins from the viewpoint of the general and specific functions they provide and their involvement in the dynamic behaviour of a cell. Content will range from basic protein structure and function to consideration of cell type-specific features and the consequences of diseaseassociated changes and potential therapeutic intervention. So that the books represent the most up-to-date understanding, contributors will be prominent researchers in each particular area. Although aimed at graduate, postgraduate and principal investigators, the books will also be of use to science and medical undergraduates and to those wishing to understand basic cellular processes and develop novel therapeutic interventions for specific diseases. More information about this series at http://www.springer.com/series/6442
Riekelt H. Houtkooper Editor
Sirtuins
Editor Riekelt H. Houtkooper Laboratory Genetic Metabolic Diseases Academic Medical Center Amsterdam, The Netherlands
Proteins and Cell Regulation ISBN 978-94-024-0961-1 ISBN 978-94-024-0962-8 (eBook) DOI 10.1007/978-94-024-0962-8 Library of Congress Control Number: 2016955084 © Springer Science+Business Media Dordrecht 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this p
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