Sirtuins family as a target in endothelial cell dysfunction: implications for vascular ageing
- PDF / 672,820 Bytes
- 22 Pages / 547.087 x 737.008 pts Page_size
- 32 Downloads / 194 Views
(0123456789().,-volV) (0123456789().,-volV)
REVIEW ARTICLE
Sirtuins family as a target in endothelial cell dysfunction: implications for vascular ageing Hai-na Zhang . Ying Dai . Chun-hong Zhang . Alfred Martin Omondi . Arunima Ghosh . Ipsita Khanra . Manas Chakraborty . Xu-ben Yu . Jing Liang
Received: 3 December 2019 / Accepted: 20 March 2020 Ó Springer Nature B.V. 2020
Abstract The vascular endothelium is a protective barrier between the bloodstream and the vasculature that may be disrupted by different factors such as the presence of diseased states. Diseases like diabetes and obesity pose a great risk toward endothelial cell inflammation and oxidative stress, leading to endothelial cell dysfunction and thereby cardiovascular complications such as atherosclerosis. Sirtuins are NAD?dependent histone deacetylases that are implicated in the pathophysiology of cardiovascular diseases, and
they have been identified to be important regulators of endothelial cell function. A handful of recent studies suggest that disbalance in the regulation of endothelial sirtuins, mainly sirtuin 1 (SIRT1), contributes to endothelial cell dysfunction. Herein, we summarize how SIRT1 and other sirtuins may contribute to endothelial cell function and how presence of diseased conditions may alter their expressions to cause endothelial dysfunction. Moreover, we discuss how the beneficial effects of exercise on the endothelium
H. Zhang Y. Dai C. Zhang X. Yu (&) J. Liang (&) Department of Pharmacy, and Zhejiang Provincial Key Laboratory of Ageing and Neurological Disorder Research, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China e-mail: [email protected]
M. Chakraborty School of Medicine, Deakin University, Geelong, Australia
J. Liang e-mail: [email protected]
X. Yu Department of Ultrasonography, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
A. M. Omondi Institute of Primate Research, Nairobi, Kenya A. Ghosh Department of Medical Coding Analysis - Emblem Health, Cognizant Technology Solutions India Pvt Ltd., Bangalore, India I. Khanra Sarvodaya School of Nursing, Rajiv Gandhi University of Health Sciences, Bangalore, India
123
Biogerontology
are dependent on SIRT1. These mainly include regulation of signaling pathways related to endothelial nitric oxide synthase phosphorylation and nitric oxide production, mitochondrial biogenesis and mitochondria-mediated apoptotic pathways, oxidative stress and inflammatory pathways. Sirtuins as modulators of the adverse conditions in the endothelium hold a promising therapeutic potential for health conditions related to endothelial dysfunction and vascular ageing. Keywords Angiogenesis Exercise Inflammation miRNA Nitric oxide Vascular endothelium
Introduction The vascular endothelium is a protective barrier lining in between the bloodstream and the vasculature. Although the earlier concepts about the endothelium considered it as a mechanical barrier only, newer studies have evidenced its broader role in the regulat
Data Loading...
