Sodium Channels, Pain, and Analgesia
Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervo
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Series Editor Prof. Michael J. Parnham PhD Senior Scientific Advisor PLIVA Research Institute Ltd. Prilaz baruna Filipovic´a 29 HR-10000 Zagreb Croatia Advisory Board G. Z. Feuerstein (Merck Research Laboratories, West Point, PA, USA) M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a. d. Riss, Germany) W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)
Forthcoming titles: Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation, A.B. Malmberg, K.R. Bley (Editors), 2005 NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis and Cancer, G.Z. Feuerstein, Z. Zukowska (Editors), 2005 Complement and Kidney Disease, P.F. Zipfel (Editor), 2005 Chemokine Biology: Basic Research and Clinical Application, Volume I: Immunobiology of Chemokines, K. Neote, L.G. Letts, B. Moser (Editors), 2005 Chemokine Biology: Basic Research and Clinical Application, Volume II: Pathophysiology of Chemokines, K. Neote, L.G. Letts, B. Moser (Editors), 2005 The Hereditary Basis of Rheumatic Diseases, R. Holmdahl (Editor), 2005 (Already published titles see last page.)
Sodium Channels, Pain, and Analgesia
Kevin Coward Mark D. Baker Editors
Birkhäuser Verlag Basel · Boston · Berlin
Editors Kevin Coward Department of Pharmacology University of Oxford Mansfield Road Oxford OX1 3QT UK
Mark D. Baker Molecular Nociception Group Department of Biology Medawar Building University College London Gower Street London WC1E 6BT UK
Library of Congress Cataloging-in-Publication Data Sodium channels, pain, and analgesia / Kevin Coward, Mark D. Baker, editors. p. ; cm. -- (Progress in inflammation research) Includes bibliographical references and index. ISBN 3-7643-7062-9 (alk. paper) 1. Pain. 2. Sodium channels. 3. Analgesics. I. Coward, Kevin, 1969– II. Baker, Mark D., 1960III. PIR (Series) RB127.S64 2005 616’.0472--dc22 2005048132 Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de
The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use.
ISBN-10: 3-7643-7062-9 Birkhäuser Verlag, Basel – Boston – Berlin ISBN-13: 978-3-7643-7062-6 Birkhäuser Verlag, Basel – Boston – Berlin This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. © 2005 Birkhäuser Verlag,
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