Sodium-Glucose Co-Transport Inhibitors
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Sodium-Glucose Co-Transport Inhibitors Progress and Therapeutic Potential in Type 2 Diabetes Mellitus Joshua J. Neumiller,1 John R. White Jr1 and R. Keith Campbell2 1 Department of Pharmacotherapy, College of Pharmacy, Washington State University, Spokane, Washington, USA 2 Department of Pharmacotherapy, College of Pharmacy, Washington State University, Pullman, Washington, USA
Abstract
The kidney plays a major role in glucose homeostasis because of its role in gluconeogenesis and the glomerular filtration and reabsorption of glucose in the proximal convoluted tubules. Approximately 180 g of glucose is filtered daily in the glomeruli of a normal healthy adult. Typically, all of this glucose is reabsorbed with
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