Solid component ratio influences prognosis of GGO-featured IA stage invasive lung adenocarcinoma
- PDF / 1,046,130 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 89 Downloads / 148 Views
RESEARCH ARTICLE
Open Access
Solid component ratio influences prognosis of GGO-featured IA stage invasive lung adenocarcinoma Fenghao Sun†, Yiwei Huang†, Xiaodong Yang, Cheng Zhan, Junjie Xi, Zongwu Lin, Yu Shi, Wei Jiang and Qun Wang*
Abstract Background: The computed tomography (CT) characteristic of ground glass opacity (GGO) were shown to be associated with clinical significance in lung adenocarcinoma. We evaluated the prognostic value of the solid component ratio of GGO IA invasive lung adenocarcinoma. Methods: We retrospectively analyzed the records of GGO IA patients who received surgical resection from April 2012 to December 2015. The solid component ratio was calculated based on thin-slice CT scans. Baseline features were compared stratified by the ratio. Cox proportional hazard models and survival analyses were adopted to explore potential prognostic value regarding overall survival (OS) and disease-free survival (DFS). Results: Four hundred fifteen patients were included. The higher ratio was significantly associated with larger tumor diameter, pathological subtypes and choice of surgical type. There was a significantly worse DFS with a > 50% ratio. The subgroups of 0% and ≤ 50% ratio showed close survival curves of DFS. Similar trends were observed in OS. Multivariate analyses revealed that the ratio was a significant predictor for DFS, but not for OS. No significant prognostic difference was observed between lobectomy and limited resections. Conclusion: A higher solid component ratio may help to predict a significantly worse prognosis of GGO IA lung adenocarcinoma. Keywords: Lung adenocarcinoma, Solid component ratio, Ground glass opacity, Prognosis
Synopsis The higher ratio of solid component was significantly associated with clinicopathological features of GGO patients with IA stage disease, such as tumor diameter and pathological subtype. A higher solid component ratio may help to predict a significantly worse prognosis of GGO IA lung adenocarcinoma.
* Correspondence: [email protected] † Fenghao Sun and Yiwei Huang contributed equally to this work. Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, No. 180, Fenglin Road, Shanghai 200032, China
Introduction Lung adenocarcinoma is the most common histological subtype of non-small cell lung cancer with high morbidity and mortality worldwide, which also presents an increasing incidence rate [1]. Early stage lung adenocarcinoma is often detected as showing ground glass opacity (GGO) in thoracic thin-slice computed tomography (CT). In 2011, the International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society proposed a new multidisciplinary classification system for lung adenocarcinoma, which were mainly composed of adenocarcinoma in situ,
© The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you gi
Data Loading...
