Spatial distribution of the dropless ESI charged particles at IMS entrance
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ORIGINAL RESEARCH
Spatial distribution of the dropless ESI charged particles at IMS entrance E. M. Mutin 1 & M. Z. Muradymov 2 & N. V. Krasnov 2 & M. N. Krasnov 3 & I. V. Kurnin 2 Received: 17 July 2020 / Revised: 28 August 2020 / Accepted: 1 September 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract An experimental study and comparison of spatial distributions of charged particles for conventional electrospray (ESI) and for dropless electrospray with a dynamic flow splitter of analyzed solution at atmospheric pressure and room temperature was carried out. Comparison of distributions shows that the characteristic regions of ion formation differ significantly. The obtained dropless electrospay spatial distributions are matched with inlet parameters of optimized transfer system of an ion mobility spectrometer (IMS) based on electrostatic focusing of the charged particles. Keywords Ion flow . Electrospray . Ion mobility spectra . Dynamic liquid flow splitter
Introduction Recently, interest in ESI-IMS and LC-ESI-IMS-o-TOFMS has been increasing. In the LC-ESI-IMS-o-TOFMS instrument complexes, micro- or nano-electrospray is used at atmospheric pressure [4, 5, 7]. However, the existing micro-drop component affects the performance of the grid gate (such as BradburyNielsen gate, Tyndall-Powell gate etc) of the ion mobility spectrometer. To address this, hot co-current gas near the sprayer and hot drift gas in the ion mobility analyzer are used. Electrospray ion source with a dynamic liquid flow splitter was proposed in [2, 8]. Pumping out the excess vapor-gas mixture from the sputtering area (meniscus of liquid) allows under normal conditions not to overload the drift zone of the spectrometer with eluent vapor and not to splutter the ion gate with drops. The effectiveness of this approach was shown in [1]. The combination does not require additional hot gas flows, and the value of the eluent flow introduced into the sprayer is well combined with
* I. V. Kurnin [email protected] 1
Peter the Great Saint-Petersburg Polytechnic University, Politekhnicheskaya str., 29, Saint-Petersburg 195251, Russia
2
Institute for Analytical Instrumentation of the Russian Academy of Science, Ivana Chernykh str., 31-33, Saint-Petersburg 198095, Russia
3
Device Consulting Ltd., room 45, 6-A, Aerodromnaya str, Saint-Petersburg 197348, Russia
LC. In [1, 8] the advantage of electrospray ion source with dynamic splitting of analyzed solution in comparison with conventional electrospray spraying was demonstrated. The mobility spectra obtained using an electrospray with dynamic flow splitter of the sprayed liquid do not contain false random responses caused by microdrops of non-evaporated solvent (Fig. 1a, b). On the other hand, the efficiency of electrostatic focusing of ions in a source with ionization at atmospheric pressure (corona discharge) is shown: experimental studies of electrode geometry and electrical parameters of ion sources with ionization at atmospheric pressure influence on the ion movement from
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