Spatial Normalization Using Early-Phase [ 18 F]FP-CIT PET for Quantification of Striatal Dopamine Transporter Binding
- PDF / 4,430,539 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 26 Downloads / 176 Views
ORIGINAL ARTICLE
Spatial Normalization Using Early-Phase [18F]FP-CIT PET for Quantification of Striatal Dopamine Transporter Binding Sungwoo Bae 1,2 & Hongyoon Choi 1,3 & Wonseok Whi 1,2 & Jin Chul Paeng 1,3 & Gi Jeong Cheon 1,3,4 & Keon Wook Kang 1,3,4 & Dong Soo Lee 1,2,3 Received: 16 July 2020 / Revised: 6 October 2020 / Accepted: 8 October 2020 # Korean Society of Nuclear Medicine 2020
Abstract Purpose The precise quantification of dopamine transporter (DAT) density on N-(3-[18F]Fluoropropyl)-2β-carbomethoxy3β-(4-iodophenyl) nortropane positron emission tomography ([18F]FP-CIT PET) imaging is crucial to measure the degree of striatal DAT loss in patients with parkinsonism. The quantitative analysis requires a spatial normalization process based on a template brain. Since the spatial normalization method based on a delayed-phase PET has limited performance, we suggest an early-phase PET-based method and compared its accuracy, referring to the MRI-based approach as a gold standard. Methods A total of 39 referred patients from the movement disorder clinic who underwent dual-phase [18F]FP-CIT PET and took MRI within 1 year were retrospectively analyzed. The three spatial normalization methods were applied for quantification of [18F]FPCIT PET-MRI-based anatomical normalization, PET template-based method based on delayed PET, and that based on early PET. The striatal binding ratios (BRs) were compared, and voxelwise paired t tests were implemented between different methods. Results The early image-based normalization showed concordant patterns of putaminal [18F]FP-CIT binding with an MRI-based method. The BRs of the putamen from the MRI-based approach showed higher agreement with early image- than delayed imagebased method as presented by Bland-Altman plots and intraclass correlation coefficients (early image-based, 0.980; delayed image-based, 0.895). The voxelwise test exhibited a smaller volume of significantly different counts in putamen between brains processed by early image and MRI compared to that between delayed image and MRI. Conclusion The early-phase [18F]FP-CIT PET can be utilized for spatial normalization of delayed PET image when the MRI image is unavailable and presents better performance than the delayed template-based method in quantitation of putaminal binding ratio. Keywords Dopamine transporter imaging . [18F]FP-CIT PET . Early-phase image . Spatial normalization . Quantitative analysis
Introduction Dopamine transporter (DAT) imaging has been widely applied to evaluate the function of presynaptic dopaminergic * Hongyoon Choi [email protected] 1
Department of Nuclear Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea
2
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea
3
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
4
Institute of Radiation Medicine, Medical Re
Data Loading...
