Spherical Crystallization as a New Platform for Particle Design Engineering

This book describes the principles and applications of the spherical crystallization technique, from the standpoint of its inventor. After an introduction on the history of particle design engineering and nanotechnology, the concept of spherical crystalli

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Spherical Crystallization as a New Platform for Particle Design Engineering

Spherical Crystallization as a New Platform for Particle Design Engineering

Yoshiaki Kawashima

Spherical Crystallization as a New Platform for Particle Design Engineering

Yoshiaki Kawashima Department of Pharmaceutical Engineering, Faculty of Pharmacy Aichi Gakuin University Nagoya, Japan

ISBN 978-981-13-6785-4    ISBN 978-981-13-6786-1 (eBook) https://doi.org/10.1007/978-981-13-6786-1 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

To late Takako, Tomoko, Akiko, and Shigefumi

Foreword: Comments for Spherical Crystallization, a New Platform for Particle Design Engineering 

It is an honor to comment on the new book Spherical Crystallization as a New Platform for Particle Design Engineering of Professor Yoshiaki Kawashima’s excellent oeuvre as a result of his lifetime commitment to the theory and practice of the spherical crystallization process. Professor Kawashima’s work on spherical crystallization is well organized and consists of eight chapters. The first chapter is focused on the new engineering concept of “particle design engineering” being the primary goal of powder technology. To push forward the initial impulse of this concept is the result of the seminal publication of G. L. Amidon et al. in Pharm. Res. 12 (3): 413–20 (March 1995) with respect to the Biopharmaceutics Classification System (BCS) [https://en.wikipedia.org/wiki/Biopharmaceutics_Classification_ System] followed by in-depth discussions within the following organizations: Division of Pharmaceutical Preparations and Particulate Design (PPD) of the Society of Powder Te