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atistical Modeling for Biological Systems In Memory of Andrei Yakovlev

Statistical Modeling for Biological Systems

Anthony Almudevar • David Oakes • Jack Hall Editors

Statistical Modeling for Biological Systems In Memory of Andrei Yakovlev

Editors Anthony Almudevar Department of Biostatistics and Computational Biology University of Rochester Medical Center Rochester, NY, USA

David Oakes Department of Biostatistics and Computational Biology University of Rochester Medical Center Rochester, NY, USA

Jack Hall (deceased) Rochester, NY, USA

ISBN 978-3-030-34674-4 ISBN 978-3-030-34675-1 (eBook) https://doi.org/10.1007/978-3-030-34675-1 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Preface

November 30, 2019, was the 75th anniversary of the birth of Andrei Yakovlev, an extraordinary scholar and inspirational leader. To mark the anniversary, we present this volume of papers dedicated to his memory. The contributors include collaborators, colleagues, and other members of the statistical community influenced by him. Many of the papers grew out of a conference in his honor, held in Rochester in June 2009. Here is a summary sketch of his life and achievements, drawn extensively from his obituary in the IMS Bulletin.1 A full list of publications is included in this volume as an Appendix. Andrei Yakovlev was born in 1944 in Leningrad (now St. Petersburg), Russia; his father was a mathematician and senior naval officer. Although engrossed in mathematics—often carrying a mathematics book about as a child—he sought a different career. He earned an MD (Leningrad, 1967), followed by a PhD in cell biology (Pavlov Institute of Physiology, 1973) and a DSc in

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