Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy
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Biophysics Reports
REVIEW
Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy Yingsi Xie1,3, Ruslan G. Tuguntaev1, Cong Mao1, Haoting Chen1, Ying Tao1, Shixiang Wang4&, Bin Yang2&, Weisheng Guo1& 1
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Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China The Sixth Affiliated Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China Universite´ Paris 13, 99 avenue Jean Baptiste Cle´ment, 93430 Villetaneuse, France Department of Cardiovascular Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China
Received: 1 June 2020 / Accepted: 15 July 2020 / Published online: 6 October 2020
Abstract
Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane. Current therapeutic strategies for RA mainly aim to hamper the macrophages’ proliferation and reduce the production of pro-inflammatory cytokines. Therefore, the accumulation of therapeutic agents targeted at the inflammatory site should be a crucial therapeutic strategy. Nowadays, the nanocarrier system incorporated with stimuli-responsive property is being intensively studied, showing the potentially tremendous value of specific therapy. Stimuli-responsive (i.e., pH, temperature, light, redox, and enzyme) polymeric nanomaterials, as an important component of nanoparticulate carriers, have been intensively developed for various diseases treatment. A survey of the literature suggests that the use of targeted nanocarriers to deliver therapeutic agents (nanotherapeutics) in the treatment of inflammatory arthritis remains largely unexplored. The lack of suitable stimuli-sensitive polymeric nanomaterials is one of the limitations. Herein, we provide an overview of drug delivery systems prepared from commonly used stimuli-sensitive polymeric nanomaterials and some inorganic agents that have potential in the treatment of RA. The current situation and challenges are also discussed to stimulate a novel thinking about the development of nanomedicine.
Keywords Rheumatoid arthritis, Nanotechnology, Stimuli-responsive polymers, Drug delivery systems
INTRODUCTION Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane (McInnes and O’Dell 2010; McInnes Yingsi Xie and Ruslan G. Tuguntaev contributed equally to this work. & Correspondence: [email protected] (S. Wang), [email protected] (B. Yang), [email protected] (W. Guo)
Ó The Author(s) 2020
and Schett 2017; Smolen et al. 2012). It causes clinically acute pain, swelling, progressive cartilage damage, and bone erosion, which severely affects life quality, even increases the mortality rate (Oliveira et al. 2018). While the cause of rheumatoid arthritis is not very clear, the underlying mechanism of pathoge
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