Stratum Corneum

The stratum corneum is a magnificent example of the successful adaptation of a tissue. Its efficient function is a prerequisite for life itself. We depend on its control of the movement of water through the skin and on its protective role in the preventio

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Springer¥erlag Berlin Heidelberg New York 1983

Professor Ronald Marks University of Wales, Welsh National School of Medicine Department of Medicine Heath Park, Cardiff CF4 4XN, Great Britain Professor Dr. Gerd Plewig U niversitatshautklinik MoorenstraBe 5 4000 Dusseldorf 1, FRG

ISBN -13: 978-3-540-11704-9 e- ISBN -13: 978-3-642-68682-5 DOl: 10.1007/978-3-642-68682-5 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law, where copies are made for other than private use, a fee is payable to 'Verwertungsgesellschaft Wort', Munich. © Springer-Verlag Berlin Heidelberg 1983 The use of registered names, trademarks, etc. in the publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceuticalliterature. 2127/3140-543210

Preface

The stratum corneum is a magnificent example of the successful adaptation of a tissue. Its efficient function is a prerequisite for life itself. We depend on its control of the movement of water through the skin and on its protective role in the prevention of penetration by pathogens or harmful substances. Apart from its functional importance, there is no escaping the fact that the most common skin disorders (psoriasis, eczema, inherited disorders of keratinization, acne) are 'characterised by abnormal keratinization and or scaliness. Despite all this, understanding of its chemistry, structure, physiology and involvement in disease has been sadly deficient; however, there are signs of enlightenment. This symposium is evidence of changed atti· tudes. Leading researchers from many countries have applied modem biomedical techniques and the methods of molecular biology to the many problems and questions posed by the stratum corneum. Although there have been several symposia and publications on the process of keratinization, few have been broadly based on the stratum corneum. For this reason we believe that the proceedings of this symposium will be invaluable for all who are profeSSionally concerned with skin biology. Cardiff/Diisseldorf, November 1982

R. Marks G. Plewig

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Acknowledgements

Alcon Labs. Limited Brocades G.B. Limited Cardiff City Council Cassella-Riedel Pharma GmbH. Cilag-Chemie Dermal Laboratories Limited Dista Products Limited Dome Div. Miles Laboratories Limited Hoechst AG. Imperial Chemical Industries Limited Janssen Pharmaceuticals Limited Johnson & Johnson Limited L'Oreal E. Merck Organon Scientific Development Group Pfizer Limited Quinoderm Limited Scheri