Stroke Genetics
This revised, expanded second edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrov
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Stroke Genetics Second Edition
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Stroke Genetics
Pankaj Sharma • James F. Meschia Editors
Stroke Genetics Second Edition
Editors Pankaj Sharma Department of Neurology Institute of Cardiovascular Research Royal Holloway College, University of London Imperial College London Healthcare NHS Trust London, UK
James F. Meschia Department of Neurology Mayo Clinic Jacksonville, Florida USA
ISBN 978-3-319-56208-7 ISBN 978-3-319-56210-0 (eBook) DOI 10.1007/978-3-319-56210-0 Library of Congress Control Number: 2017941720 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
So they told us that writing a second edition is a whole lot easier than writing the first. Don’t believe them! Without the support of our families this second edition would never have seen the light of day. For that, we dedicate it to Sapna, Aarti, Shyam, Diana, Catherine, Camille, and James.
Preface
We introduced our first edition of this book with the statement that ‘our understanding of the genetics of common diseases has come a long way in recent years’. That statement is as true now as it was then but even we could not have foretold the enormous strides being made in the genetics of all the common diseases, with stroke being an exemplar of the complexity and struggles of that science. The advances in our mathematical and statistical capabilities along with the strides in genetic laboratories and, just as importantly, the reduction in manufacturing cost of microarray chip technology have all helped in greatly improving our understanding of stroke genetics. Many thousands of willing patients have agreed to donate their DNA
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