Structure and Function of GPCRs
This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs.
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Guillaume Lebon Editor
Structure and Function of GPCRs
30
Topics in Medicinal Chemistry
Series Editors P.R. Bernstein, Philadelphia, USA A.L. Garner, Ann Arbor, USA G.I. Georg, Minneapolis, USA T. Kobayashi, Tokyo, Japan J.A. Lowe, Stonington, USA N.A. Meanwell, Princeton, USA A.K. Saxena, Lucknow, India U. Stilz, Boston, USA C.T. Supuran, Sesto Fiorentino, Italy A. Zhang, Pudong, China
Aims and Scope Topics in Medicinal Chemistry (TMC) covers all relevant aspects of medicinal chemistry research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. To fulfil this need, TMC is intended for researchers and experts working in academia and in the pharmaceutical industry, and also for graduates that look for a carefully selected collection of high quality review articles on their respective field of expertise. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. All chapters from Topics in Medicinal Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Medicinal Chemistry is abbreviated as Top Med Chem and cited as a journal. More information about this series at http://www.springer.com/series/7355
Guillaume Lebon Editor
Structure and Function of GPCRs With contributions by F. Acher J.-L. Banères S.S. Bhunia J. Carlsson M. Casiraghi L.J. Catoire T. Durroux O. Faklaris A. Falco C. Goudet E. Goyet J. Heuninck F.G. Jean-Alphonse G. Lebon A. Llebaria C. Mendre B. Mouillac C. Nasrallah J. Perroy J.-P. Pin A. Ranganathan D. Rodríguez P. Rondard X. Rovira A.K. Saxena M. Saxena I. Sutkeviciute M. Tian A.J. Venkatakrishnan J.-P. Vilardaga Q. Wang S. Ye C. Yuan J.M. Zwier
Editor Guillaume Lebon Institut de Génomique Fonctionnelle Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM) University of Montpellier Montpellier, France
ISSN 1862-2461 ISSN 1862-247X (electronic) Topics in Medicinal Chemistry ISBN 978-3-030-24589-4 ISBN 978-3-030-24591-7 (eBook) https://doi.org/10.1007/978-3-030-24591-7 © Springer Nature Switzerland AG 2019 This work is subject to
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