Studies on Experimental Models
There is a widespread consensus that use of antioxidants as a therapeutic approach may counteract free radical mediated pathologies. However, the role of antioxidants in normal physiology and redox signaling is still in its infancy. Since oxidative stress
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Editor-in-Chief Donald Armstrong
For other titles published in this series, go to www.springer.com/series/8145
Note from the Editor-in-Chief All books in this series illustrate point-of-care testing and critically evaluate the potential of antioxidant supplementation in various medical disorders associated with oxidative stress. Future volumes will be updated as warranted by emerging new technology, or from studies reporting clinical trials. Donald Armstrong Editor-in-Chief
Samar Basu • Lars Wiklund Editors
Studies on Experimental Models
Editors Samar Basu Professor of Biochemistry and Medical Inflammation Director of Chaire d’Excellence Laboratorie de Biochimie Biologie Moléculaire et Nutrition Faculté de Pharmacie Université d’Auvergne 28 Place Henri-Dunant BP 38 63001 Clermont-Ferrand France and Head, Oxidative stress and Inflammation Department of Public Health and Caring Sciences Faculty of Medicine Uppsala University SE-751 85 Uppsala Sweden [email protected] [email protected]
Lars Wiklund Professor of Anesthesiology and Intensive Care Medicine Department of Surgical Sciences/ Anesthesiology and Intensive Care Medicine Faculty of Medicine Uppsala University SE-751 85 Uppsala Sweden [email protected]
ISBN 978-1-60761-955-0 e-ISBN 978-1-60761-956-7 DOI 10.1007/978-1-60761-956-7 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011923976 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface
The notion that reactive oxygen species are involved in diseases originated in the 1930s when scientists realized that radiation injury may lead to formation of free radicals and in turn initiate cancer and other pathologies. Even though research in free radicals has been stretched exponentially in the last three decades, there are still major questions as to what extent free radicals are involved in health and various diseases. In recent years, there is a growing recognition that free radicals, and thereby oxidative stress, is involved in atherosclerosis, cardiovascular diseases, cancer, ischemia–reperfusion injury, radiation injury and neurological diseases, etc. In addition, free radicals are perhaps involved in both agi
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