Studies on Experimental Toxicology and Pharmacology
This book focuses on data describing the roles of free radicals and related reactive species, and antioxidants, in the causes and treatments of diseases, examining both clinical and pre-clinical trials, as well as basic research. The book is divided into
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Stephen M. Roberts James P. Kehrer Lars-Oliver Klotz Editors
Studies on Experimental Toxicology and Pharmacology
Oxidative Stress in Applied Basic Research and Clinical Practice Editor-in-Chief Donald Armstrong
Note from the Editor-in-Chief All books in this series illustrate point-of-care testing and critically evaluate the potential of antioxidant supplementation in various medical disorders associated with oxidative stress. Future volumes will be updated as warranted by emerging new technology, or from studies reporting clinical trials. Donald Armstrong Editor-in-Chief
More information about this series at http://www.springer.com/series/8145
Stephen M. Roberts • James P. Kehrer Lars-Oliver Klotz Editors
Studies on Experimental Toxicology and Pharmacology
Editors Stephen M. Roberts Center for Environmental & Human Toxicology University of Florida Gainesville, FL, USA
James P. Kehrer Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton, AB, Canada
Lars-Oliver Klotz Department of Nutrigenomics Institute of Nutrition, Friedrich Schiller University Jena Jena, Thüringen, Germany
ISSN 2197-7224 ISSN 2197-7232 (electronic) Oxidative Stress in Applied Basic Research and Clinical Practice ISBN 978-3-319-19095-2 ISBN 978-3-319-19096-9 (eBook) DOI 10.1007/978-3-319-19096-9 Library of Congress Control Number: 2015951628 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Contents
Part I Toxicological Mechanisms and Evaluation of Oxidative Stress 1
2
3
A Historical Perspective on Oxidative Stress and Intracellular Redox Control ........................................................... Ethiene Castellucci Estevam, Muhammad Jawad Nasim, Lisa Faulstich, Marina Hakenesch, T
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