Studies on Veterinary Medicine
This compendium of research material on the role of oxidative stress in animal disease and morbidity examines both the general and the specific. Sourced from scientists, veterinarians, and members of the medical community from around the world, it include
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Editor-in-Chief Donald Armstrong
For other titles published in this series, go to http://www.springer.com/series/8145
Note from the Editor-in-Chief All books in this series illustrate point-of-care testing and critically evaluate the potential of antioxidant supplementation in various medical disorders associated with oxidative stress. Future volumes will be updated as warranted by emerging new technology, or from studies reporting clinical trials. Donald Armstrong Editor-in-Chief
Lester Mandelker Peter Vajdovich ●
Editors
Studies on Veterinary Medicine
Editors Lester Mandelker Fellow, American Academy of Veterinary Pharmacology and Therapeutics Community Veterinary Hospital Largo, FL 33770, USA [email protected]
Peter Vajdovich Faculty of Veterinary Sciences Department of Internal Medicine and Clinics Szent Istvan University Istvan u. 2, 1143, Budapest, Hungary [email protected]
ISBN 978-1-61779-070-6 e-ISBN 978-1-61779-071-3 DOI 10.1007/978-1-61779-071-3 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011921347 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or im-plied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface
The production of free radicals (ROS) is an unavoidable consequence of life in an aerobic environment. Free radicals produced from the metabolic activities of oxygen attack biological membranes and lipoproteins via oxidation in a process called lipid perioxidation. This attack damages cells and lipids often in a chain reaction with carbon-based molecules such as polyunsaturated fatty acids (PUFA) in a reaction with molecular oxygen. This creates oxidative stress and damage to tissues. Free radicals also damage chromosomal DNA. It is more likely that damage to DNA occurs from external sources rather than mitochondrial-produced free radicals. Synthetic compounds, pollutants, radiation, xenobiotics (drugs), and food co
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