Transfusion Medicine Case Studies and Clinical Management

Transfusion Medicine: Case Studies and Clinical Management is an excellent way to illustrate current thinking about how to manage common transfusion medicine problems. The case studies and their accompanying commentaries provide a practical and enjoyable

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Aleksandar Mijovic

Transfusion Medicine Case Studies and Clinical Management

Dr. Aleksandar Mijovic Kings College Hospital Haematology Denmark Hill SE5 9RS London United Kingdom

ISBN 978-1-4471-2181-7 e-ISBN 978-1-4471-2182-4 DOI 10.1007/978-1-4471-2182-4 Springer London Dordrecht Heidelberg New York British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library Library of Congress Control Number: 2011941402 © Springer-Verlag London Limited 2012 Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted under the Copyright, Designs and Patents Act 1988, this publication may only be reproduced, stored or transmitted, in any form or by any means, with the prior permission in writing of the publishers, or in the case of reprographic reproduction in accordance with the terms of licenses issued by the Copyright Licensing Agency. Enquiries concerning reproduction outside those terms should be sent to the publishers. The use of registered names, trademarks, etc., in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore free for general use. Product liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

I dedicate this book to the memory of my parents, Gordana and Slobodan Mijovic, with Love and Gratitude. Aleksandar Mijovic

Foreword

Blood transfusion has come a long way since the discovery of ABO blood groups by Landsteiner in 1900. It has progressed so much that it has become an integral part of modern clinical practice, including surgery, maternity, trauma, cancer care, and organ and tissue transplantation. It is not surprising that a new term “transfusion medicine” has been coined to encompass the clinical practice of blood transfusion and related activities as well as the more traditional laboratory aspects of compatibility testing and the identification of red cell antibodies. The increased understanding of blood cells and hemostasis through advances in immunology and molecular biology is also very much a part of modern transfusion medicine. Given that some aspect of transfusion medicine plays a part in so many patients’ clinical care, it is essential for busy clinicians to have a sound understanding of the science which underpins the use of blood, stem cells, tissues, and organs and the investigation and management of patients with immune blood disorders such as hemolytic disease of the newborn. There are several large- and medium-sized textbooks of transfusion medicine, primarily aimed at the transfusion specialist, but very few small textbooks for doctors, nurses, and scientists who are non-specialists. Even rare