Surface Coating Modified Polyglycolide (PGA) Braided Threads as Potential Thread-embedding Materials
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ISSN 1229-9197 (print version) ISSN 1875-0052 (electronic version)
Surface Coating Modified Polyglycolide (PGA) Braided Threads as Potential Thread-embedding Materials Shaoju Fu1,2 and Peihua Zhang1,2* 1
Engineering Research Center of Technical Textiles Ministry of Education, College of Textiles, Donghua University, Songjiang District, Shanghai 201620, China 2 Key Laboratory of Textile Science and Technology, Ministry of Education, Donghua University, Shanghai 201620, China (Received December 18, 2019; Revised February 5, 2020; Accepted February 10, 2020) Abstract: Polyglycolic acid (PGA) braided threads offer numerous advantages, including good biocompatibility and biodegradability for the application of acupoint catgut-embedding therapy (ACET). However, the surfaces of PGA threads are relatively smooth and lack some function characteristics in the clinical practice. In this study, four types of PGA braided threads with different strands (n=2, 4, 6 and 8) were fabricated firstly, and then to deposit chitosan molecules on their surfaces. Afterwards, characterizations such surface morphology, swelling, mechanical, antibacterial and cytotoxicity properties of threads were fully explored. The results showed that PGA threads after chitosan coating treatment showed larger weight and diameter changing, and swelling ratio. Mechanical properties (breaking strength, breaking elongation and flexibility) had been greatly improved after coating treatment. As for the biological experiments, modified PGA threads have better cell viability and antibacterial activity comparted to that of unmodified ones. In conclusion, surface coating method warrant further study to develop novel PGA embedding materials with outstanding clinical efficacy. Keywords: Acupoint catgut-embedding therapy (ACET), Braided threads, Surface coating, Antibacterial activity
functional characteristics. Thus, ACET materials combining the advantages of both natural and synthetic biodegradable materials are deserved to make further studies [11]. There are increasing numbers of recent examples where ACET materials have been treated with some surface modified methods, including surface coating [12], plasma [13], physical vapor deposition [14], etc. Among these materials, PGA exhibited many superiorities in practical application, which is cheap and readily available, and possess good flexibility and biodegradable properties [15]. Umair et al. [16] deposited the N-halamine multilayers on PGA sutures using a layer-by-layer assembly technique, achieving good antibacterial activities against S. aureus and E. coli, and the coated PGA sutures with 0.22 % chlorine loading showed 16.8 % hemolytic activity and 79 % cell viability. Martins et al. [17] applying cold plasma technology on the surface modification of PGA scaffolds, and the modified PGA scaffolds exhibited better hydrophilicity and cell adhesion ability. Song et al. [18] studied the effects of physical vapor deposition modification on the PGA films, and better performances such as hydrophilicity, cell compatibi
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