Surface-engineered nanostructured lipid carrier systems for synergistic combination oncotherapy of non-small cell lung c
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ORIGINAL ARTICLE
Surface‑engineered nanostructured lipid carrier systems for synergistic combination oncotherapy of non‑small cell lung cancer Shruti Rawal1 · Vivek Bora2 · Bhoomika Patel2 · Mayur Patel1 Accepted: 7 October 2020 © Controlled Release Society 2020
Abstract Nanoparticle-aided combination chemotherapy offers several advantages like ratiometric drug delivery, dose reduction, multi-targeted therapy, synergism, and overcoming multi-drug resistance. The current research was instigated to facilitate targeted and ratiometric co-delivery of docetaxel (DT) and curcumin (CR) through the development of folate (FA)–appended nanostructured lipid carriers (NLCs), i.e., FA-DTCR-NLCs to lung cancer cells. The FA-DTCR-NLCs were formulated by employing a scaleable and solvent-free high-pressure homogenization approach. The FA-DTCR-NLCs were evaluated for in vitro and in vivo characteristics using suitable analytical and statistical techniques. The FA-DTCR-NLCs demonstrated physicochemical properties and particokinetics suitable for targeted, ratiometric co-delivery of the anticancer agents. This was further affirmed by significantly better in vivo relative bioavailability of DT (24.85 fold) with FA-DTCR-NLCs as compared with Taxotere® (p
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