Surgery in Multimodal Management of Solid Tumors
Surgery continues to be the most effective treatment of solid tumors in terms of recovery, while its combination with other treatments improves the survival curves especially in the advanced forms of the disease. The aim of my task first of all has been t
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Antonio Bolognese • Luciano Izzo
Surgery in Multimodal Management of Solid Tumors In cooperation with Luigi Marchiori Silvia Pachera Luca Bortolasi Riccardo Manfredi Paola Capelli
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Antonio Bolognese Department of Surgery “Pietro Valdoni” Policlinico Umberto I La Sapienza University Rome, Italy Luciano Izzo Department of Surgery “Pietro Valdoni” Policlinico Umberto I La Sapienza University Rome, Italy
The publication and the distribution of this volume have been supported by the Italian Society of Surgery
Library of Congress Control Number: 2008936504 ISBN 978-88-470-1084-0 Springer Milan Berlin Heidelberg New York e-ISBN 978-88-470-1085-7 Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Italia 2009 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the Italian Copyright Law in its current version, and permission for use must always be obtained from Springer. Violations are liable for prosecution under the Italian Copyright Law. The use of general descriptive names, registered names, trademarks, etc., in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: Simona Colombo,Milan, Italy Typesetting: Graphostudio, Milan, Italy Printing and binding: Arti Grafiche Nidasio, Assago, Italy Printed in Italy Springer-Verlag Italia S.r.l. – Via Decembrio 28 – I-20137 Milan
For Rachele and Edoardo For their affectionate and constant closeness, which has given me the composure and balance required for the work of professor of surgery
Foreword
The contributions of science and technology are essential to sound clinical practice, as they enable a clear assessment of the clinical manifestations of disease and, in turn, form the basis for the appropriate medical or surgical treatment. There are two major parts to this volume. In the first, the relationship between cancer biology and surgery and the challenges posed by the one on the other are discussed. In the second, the contributions of biochemistry, physiology, pathology, imaging, chemotherapy, radiation therapy and surgery to the diagnosis and management of solid tumors are considered. The information is addressed not only to experienced surgeons but also to those entering or still in training. I wish to thank the distinguished specialists who have contributed to this book. Their efforts have resulted in a comprehensive review
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