Surgical Management and Outcomes of Rectal Cancer with Synchronous Prostate Cancer: A Multicenter Experience from the GR
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ORIGINAL ARTICLE – COLORECTAL CANCER
Surgical Management and Outcomes of Rectal Cancer with Synchronous Prostate Cancer: A Multicenter Experience from the GRECCAR Group Alexandre Doussot, MD, PhD1, Dewi Vernerey, PhD2, Eric Rullier, MD, PhD3, Je´re´mie H. Lefevre, MD, PhD4 , He´le`ne Meillat, MD5, Eddy Cotte, MD, PhD6, Guillaume Piessen, MD, PhD7, Jean-Jacques Tuech, MD, PhD8, Yves Panis, MD, PhD9, Diane Mege, MD, PhD10, Aure´lia Meurisse, BSc2, Berardino De Bari, MD, PhD11,12, Bruno Heyd, MD, PhD1, Zaher Lakkis, MD, PhD1 on behalf of French Research Group of Rectal Cancer Surgery (GRECCAR) 1
Department of Digestive Surgical Oncology – Liver Transplantation Unit, University Hospital of Besanc¸on, Besanc¸on Cedex, France; 2Methodological and Quality of Life Unit in Oncology, University Hospital of Besanc¸on, Besanc¸on, France; 3Department of Colorectal Surgery, Haut-Le´ve`que Hospital, Pessac, France; 4Department of Digestive Surgery, AP-HP, Hoˆpital Saint Antoine, Sorbonne Universite´, Paris, France; 5Department of Digestive Surgical Oncology, Department of Mini Invasive Interventions (DIMI), Paoli Calmettes Institute, Marseille, France; 6Department of Digestive and Oncological Surgery, Lyon Sud University Hospital, Pierre Be´nite, France; 7Department of Digestive and Oncological Surgery, Claude Huriez University Hospital, Lille, France; 8Department of Digestive Surgery, Rouen University Hospital, Rouen, France; 9Department of Colorectal Surgery, Beaujon Hospital, Clichy, France; 10Department of Digestive and General Surgery, Timone Hospital, Marseille, France; 11Department of Radiotherapy, University Hospital of Besanc¸on, Besanc¸on, France; 12Department of Radiotherapy, University Hospital of Lausanne, Lausanne, Switzerland
ABSTRACT Background. Synchronous prostate cancer (PC) and rectal cancer (RC) is a rare clinical situation. While combining curative-intent management for both cancers can be challenging, available data for guiding the multidisciplinary strategy are lacking. Methods. Consecutive patients undergoing rectal resection for a mid-low RC with synchronous PC treated at 9 tertiary-care centers between 2008 and 2018 were included. Management strategy and data on postoperative and longterm outcomes were retrospectively analyzed. Results. Overall, 25 patients underwent curative-intent RC resection combined with PC management. Nine (36%), 10 (40%) and 6 (24%) patients had low-, intermediate-, and high-risk PC, respectively. Management mostly consisted of chemoradiotherapy combined in 18 patients (72%) with either TME in 12 patients or pelvic exenteration for
Ó Society of Surgical Oncology 2020 First Received: 12 March 2020 Z. Lakkis, MD, PhD e-mail: [email protected]
resection of both cancers in 6 patients. Most patients underwent RC resection using a laparoscopic approach (n = 16, 64%). Anastomosis was performed in 18 patients (72%) of whom 13 received diverting ileostomy. The complete R0 resection rate was 96% (n = 24). The overall morbidity rate was 64% (n = 16) and 5 patients (20%) experienc
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