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BioMed Central

Open Access

Research

Susceptibility of schizophrenia and affective disorder not associated with loci on chromosome 6q in Han Chinese population Zuowei Wang1,3, Yiru Fang*1,2, Shunying Yu2, Chengmei Yuan1,2, Wu Hong1,2, Zhenghui Yi1,2, Sanduo Jiang2, R Kelsoe John4 and Zucheng Wang1 Address: 1Department of Psychiatry, School of Medicine, Shanghai JiaoTong University, Shanghai, PRoC, 2Shanghai Mental Health Center, 600 South Wan Ping Road, Shanghai, PRoC, 3Hongkou Mental Health Center of Shanghai, 159 Tongxin Road, Shanghai, PRoC and 4Departments of Psychiatry, University of California, San Diego, and San Diego VA Healthcare System, La Jolla, CA, USA Email: Zuowei Wang - [email protected]; Yiru Fang* - [email protected]; Shunying Yu - [email protected]; Chengmei Yuan - [email protected]; Wu Hong - [email protected]; Zhenghui Yi - [email protected]; Sanduo Jiang - [email protected]; R Kelsoe John - [email protected]; Zucheng Wang - [email protected] * Corresponding author

Published: 14 September 2007 Behavioral and Brain Functions 2007, 3:46

doi:10.1186/1744-9081-3-46

Received: 18 June 2007 Accepted: 14 September 2007

This article is available from: http://www.behavioralandbrainfunctions.com/content/3/1/46 © 2007 Wang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract Background: Several linkage studies across multiple population groups provide convergent support for susceptibility loci for schizophrenia – and, more recently, for affective disorder – on chromosome 6q. We explore whether schizophrenia and affective disorder have common susceptibility gene on 6q in Han Chinese population. Methods: In the present study, we genotyped 45 family trios from Han Chinese population with mixed family history of schizophrenia and affective disorder. Twelve short tandem repeat (STRs) markers were selected, which covered 102.19 cM on chromosome 6q with average spacing 9.29 cM and heterozygosity 0.78. The transmission disequilibrium test (TDT) was performed to search for susceptibility loci to schizophrenia and affective disorder. Results: The results showed STRs D6S257, D6S460, D6S1021, D6S292 and D6S1581 were associated with susceptibility to psychotic disorders. When families were grouped into schizophrenia and affective disorder group, D6S257, D6S460 and D6S1021, which map closely to the centromere of chromosome 6q, were associated with susceptibility to schizophrenia. Meanwhile, D6S1581, which maps closely to the telomere, was associated with susceptibility to affective disorder. But after correction of multiple test, all above association were changed into no significance (P > 0.05). Conclusion: These results suggest that susceptibility of schizophrenia and affective disorder not associated with loci