Symmetrical acrokeratoderma: a case series in Indian patients
- PDF / 754,476 Bytes
- 4 Pages / 595.276 x 790.866 pts Page_size
- 60 Downloads / 161 Views
LETTER TO THE EDITOR
Open Access
Symmetrical acrokeratoderma: a case series in Indian patients Keshavamurthy Vinay1, Gitesh U. Sawatkar1, Uma N. Saikia2 and Sunil Dogra1*
Abstract: Symmetrical acrokeratoderma is a recently described dermatosis in young adult males of Chinese descent. In this report, we describe a series of five cases of symmetrical acrokeratoderma from India. All 5 patients had asymptomatic, brownish-black plaques distributed symmetrically over dorsum of hand and feet with variable involvement of wrist, flexural surface of forearm, elbow, ankles, shin and knee joint. Palms and soles were characteristically spared. Typically whitish maceration of the lesions was seen after immersing in water. The disease showed exacerbation in hot and humid climate with spontaneous resolution in winter. Histopathological examination showed basket weave hyperkeratosis, irregular acanthosis and mild peri-vascular lymphomononuclear infiltrate. Loosening of the stratum corneum was seen in post-immersion biopsy specimens. Acitretin appeared to provide symptomatic improvement in the short term without any long-term effect on the natural disease course. The genetic and environmental factors involved in disease causation needs to be elucidated in future. Trial registration: The study was not registered in a trial registry since it was a retrospective analysis of the clinical records and not an interventional/observational study. Keywords: Acitretin, India, Symmetrical acral keratoderma, Symmetrical acrokeratoderma To the Editor, Symmetrical acrokeratoderma is a recently described dermatosis with distinct clinical features [1–3]. All published cases till date has been reported in patients of Chinese descent. Herein we report a series of five patients of symmetrical acrokeratoderma from India and describe the natural history, clinical, epidemiological and histopathological features and treatment outcome. A total of five patients who fulfilled the previously proposed diagnostic criteria for symmetrical acrokeratoderma were identified from our records [2]. Briefly, a diagnosis of symmetrical acrokeratoderma was established in patients who had (1) brown to black symmetrically distributed hyperkeratotic patches over acral sites but sparing palms and soles; and (2) the lesions became white and macerated rapidly after water immersion or sweating, but recovered gradually after drying [2]. All patients were males with age range of 11-31 years, belonged to the Punjab province of India and presented to us in the summer months of May, June and July 2015. * Correspondence: [email protected] 1 Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India Full list of author information is available at the end of the article
Four patients had their disease onset during adolescence with mean disease duration of 6.25years (4-8 years). One boy manifested his symptoms since infancy and presented to us at the age of 11 years. The demographic and clinica
Data Loading...
