Synaptic Mechanisms in the Auditory System

Synaptic mechanisms are the groundwork for all auditory processing. Understanding them requires knowledge of the microphysiology of synapses, cellular biophysics, and  receptor pharmacology, as well as an appreciation for what unique jobs auditory sy

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Laurence O. Trussell Richard R. Fay

L

Arthur N. Popper

Editors

Synaptic Mechanisms in the Auditory System

Editors Laurence O. Trussell Vollum Institute Oregon Health & Science University Portland, OR 97239, USA [email protected]

Arthur N. Popper Department of Biology University of Maryland College Park, MD 20742, USA [email protected]

Richard R. Fay Marine Biological Laboratory Woods Hole, MA 02543, USA [email protected]

ISBN 978-1-4419-9516-2 e-ISBN 978-1-4419-9517-9 DOI 10.1007/978-1-4419-9517-9 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011935541 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

This volume is dedicated to Professor Alan D. Grinnell, whose career has embodied the twin themes that run through the entire book, the auditory system and the physiology of synapses. Alan, along with his advisor Donald Griffin, was the first to make electrophysiological studies in the bat auditory pathway, work he continued as a faculty member at UCLA. Having also trained with Bernard Katz and Ricardo Miledi, Alan has a genuine love for the synapse, which he has expressed in a parallel research career, producing many creative and elegant studies of the physiology of the neuromuscular junction. This was all accomplished by his enormous energy and amazing breadth of knowledge. Indeed, those fortunate enough to work with him know that Alan is a consummate scholar, a deeply inquisitive scientist, and an excellent friend.

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Series Preface

The Springer Handbook of Auditory Research presents a series of comprehensive and synthetic reviews of the fundamental topics in modern auditory research. The volumes are aimed at all individuals with interest in hearing research, including advanced graduate students, postdoctoral researchers, and clinical investigators. The volumes are intended to introduce new investigators to important aspects of hearing science and to help established investigators to better understand the fundamental theories and data in fields of hearing that they may not normally follow closely. Each volume presents a particular topic comprehensively, and each serves as a synthetic