Synaptic Plasticity in Pain
Primary sensory neurons respond to peripheral stimulation by projecting to the spinal cord, where a population of neurons respond to damaging stimuli and terminate in the superficial layers of the dorsal horn. Therefore, the dorsal horns constitute the fi
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Synaptic Plasticity in Pain
Synaptic Plasticity in Pain
Marzia Malcangio Editor
Synaptic Plasticity in Pain
13
Editor Marzia Malcangio Wolfson Centre for Age Related Diseases King’s College London London SE1 1UL United Kingdom [email protected]
ISBN 978-1-4419-0225-2 e-ISBN 978-1-4419-0226-9 DOI 10.1007/978-1-4419-0226-9 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2009928134 # Springer ScienceþBusiness Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer ScienceþBusiness Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer ScienceþBusiness Media (www.springer.com)
Contents
Part I
Anatomical Plasticity of Dorsal Horn Circuits
1
Changes in NK1 and Glutamate Receptors in Pain . . . . . . . . . . . . . . Andrew J. Todd
3
2
Trophic Factors and Their Receptors in Pain Pathways. . . . . . . . . . . John V. Priestley
21
Part II
Fast Synaptic Transmission in the Dorsal Horn
3
Fast Inhibitory Transmission of Pain in the Spinal Cord . . . . . . . . . . Hanns Ulrich Zeilhofer, Robert Witschi, and Torbjorn ¨ Johansson
49
4
Synaptic Transmission of Pain in the Developing Spinal Cord . . . . . . Rachel A. Ingram, Mark L. Baccei, and Maria Fitzgerald
67
Part III
Slow Synaptic Transmission in the Dorsal Horn
5
BDNF and TrkB Mediated Mechanisms in the Spinal Cord . . . . . . . Rita Bardoni and Adalberto Merighi
6
Dorsal Horn Substance P and NK1 Receptors: Study of a Model System in Spinal Nociceptive Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Xiao-Ying Hua and Tony L. Yaksh
89
109
7
Opioidergic Transmission in the Dorsal Horn . . . . . . . . . . . . . . . . . . Juan Carlos Marvizon
139
8
CGRP in Spinal Cord Pain Mechanisms . . . . . . . . . . . . . . . . . . . . . . Volker Neugebauer
175
v
vi
Contents
Part IV 9
10
11
Amplification of Pain-Related Information
Long-Term Potentiation in Superficial Spinal Dorsal Horn: A Pain Amplifier . . . . . . . . . . . . . . . . . . . . .
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