Synthesis and Characterization of Hydrogels with Ag Nanoparticles
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MRS Advances © 2018 Materials Research Society DOI: 10.1557/adv.2018.643
Synthesis and Characterization of Hydrogels with Ag Nanoparticles K. G. H Martínez-Reyna; M. G. García-Valdivieso; H. R. Navarro-Contreras Laboratorio Nacional CIACYT-Universidad Autónoma de San Luis Potosí, Av. Sierra Leona 550, Col. Lomas 2a. Sección, C.P 78210, San Luis Potosí, S.L.P., MÉXICO.
ABSTRACT
Hydrogels made of sodium 2-acrylamide-2-methypropanesulfonate were synthesized with the goal of creating a polymer for tissue engineering applications. The hydrogels were doped with silver nanoparticles to create hydrogel/Ag with possible antibacterial properties. We varied the weight/volume percentage of Laponite from 3 to 10 w/v% to alter the rheological properties of the hydrogels. Raman spectroscopy was used to study the progress of the chemical reaction at different polymerization times under ultraviolet radiation. By comparing the changes in the intensities of the Raman bands corresponding to C=C and C–C bonds with reaction time, we found that the optimal polymerization time to obtain chains of poly(2-acrylamide-2methylpropanesulfonate) was 3 to 4 h. Characterization of the hydrogels with scanning electron microscopy indicated pore sizes of 1 to 6 µm.
INTRODUCTION Hydrogels are of great interest because of their unique properties, including ability to absorb large volumes of water, softness, flexibility and biocompatibility [1]. Hydrogels are three-dimensional, hydrophilic, polymeric networks capable of absorbing large amounts of water or biological fluids. Based on these properties, hydrogels have numerous applications in drug delivery, pesticides and tissue engineering. Tissue engineering is a method used to regenerate damaged tissue or replace organs in the body [2]. For example, injuries to menisci are the second most common knee injury, with an incidence of 61 cases per 100,000 persons [3]. This injury is common in young people (under 40 years) and especially athletes, along with patients over 65 years of age [4]. Currently, meniscus injuries are treated using transplants. While Verdonk et al. reported that 75%–90% of patients experienced fair to excellent functional results after meniscal
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allograft transplantation [5], this method of treatment has some disadvantages related to the limited number of available grafts, cost, graft sizing, effects of sterilization and preservation on the biomechanical strength of the graft, and the risk of disease transmission [6]. These factors have motived researchers to develop a new material to replace donated grafts. The design of a hydrogel-like prosthetic meniscus should incorporate several considerations. The most important factor is biocompatibility; that is, the material should not induce an immune response or severe inflammation. In the field of med
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