Synthesis and characterization of pH sensitive hydrogel nanoparticles based on poly(N-isopropyl acrylamide-co-methacryli
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SPECIAL ISSUE: HYDROGELS IN REGENERATIVE MEDICINE Original Research
Synthesis and characterization of pH sensitive hydrogel nanoparticles based on poly(N-isopropyl acrylamide-co-methacrylic acid) C. E. Belman-Flores1 W. Herrera-Kao1 R. F. Vargas-Coronado1 A. May-Pat1 A. I. Oliva2 N. Rodríguez-Fuentes3 H. Vázquez-Torres4 J. V. Cauich-Rodríguez1 J. M. Cervantes-Uc1 ●
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Received: 25 June 2019 / Accepted: 8 July 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract In this work, pH-sensitive hydrogel nanoparticles based on N-isopropyl acrylamide (NIPAM) and methacrylic acid (MAA) at various molar ratios, were synthesized and characterized in terms of physicochemical and biological properties. FTIR and 1 HNMR spectra confirmed the successful synthesis of the copolymer that formed nanoparticles. AFM images and FE-SEM micrographs showed that nanoparticles were spherical, but their round-shape was slightly compromised with MAA content; besides, the size of particles tends to decrease as MAA content increased. The hydrogels nanoparticles also exhibited an interesting pH-sensitivity, displaying changes in its particle size when changes in pH media occurred. Biological characterization results indicate that all the synthesized particles are non-cytotoxic to endothelial cells and hemocompatible, although an increase of MAA content leads to a slight increase in the hemolysis percentage. Therefore, the pH-sensitivity hydrogels may serve as a versatile platform as self-regulated drug delivery systems in response to environmental pH changes. Graphical Abstract
* J. M. Cervantes-Uc [email protected] 1
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Centro de Investigación Científica de Yucatán, A.C. Unidad de Materiales, Calle 43 No. 130 x32 y 34, Col. Chuburná de Hidalgo, Mérida, C.P. 97205 Yucatán, México Departamento de Física Aplicada, CINVESTAV-IPN, Unidad Mérida, Carretera Antigua a Progreso Km 6, Cordemex, Mérida,
C.P. 97310 Yucatán, México 3
CONACYT-Centro de Investigación Científica de Yucatán, A.C. Unidad de Materiales, Calle 43 No. 130 x32 y 34, Col. Chuburná de Hidalgo, Mérida, C.P. 97205 Yucatán, México
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Departamento de Física, Área de Polímeros, Universidad Autónoma Metropolitana-Unidad Iztapalapa, San Rafael Atlixco No. 186, Col. Vicentina, Ciudad de México C.P. 09340, México
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Journal of Materials Science: Materials in Medicine (2020)31:61
1 Introduction Hydrogels are three-dimensional networks of hydrophilic or amphiphilic polymers capable of absorbing large amounts of water or biological fluids while maintaining a semi-solid structure. Due to their high-water content, porosity and rubbery nature, they resemble closely soft living tissue more than any other class of synthetic biomaterials [1–4]. Some hydrogels have been developed to exhibit responsiveness to changes in environmental conditions such as temperature, pH, magnetic field, ionic strength, etc.; these external stimuliresponsive hydrogels are called “smart” hydrogels and have potential applications
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