Synthesis and Thermal Properties of Cobalt-Doped Hydroxyapatite Nanoparticles with Controlled Morphological Parameters
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Synthesis and Thermal Properties of Cobalt-Doped Hydroxyapatite Nanoparticles with Controlled Morphological Parameters E. A. Syukkalovaa, A. S. Veprevaa, A. V. Sadetskayaa, N. D. Demidovaa, N. P. Bobryshevaa, M. G. Osmolowskya, and O. M. Osmolovskayaa,* a St.
Petersburg State University, St. Petersburg, 199034 Russia *e-mail: [email protected]
Received July 13, 2020; revised July 16, 2020; accepted July 19, 2020
Abstract—Cobalt-doped hydroxyapatite nanoparticles with various morphological parameters were obtained, and the effect of the dopant concentration and nanoparticle morphology on their thermal properties was studied. Keywords: hydroxyapatite, nanoparticles, doping, hydrothermal synthesis, precipitation method, thermal stability
DOI: 10.1134/S1070363220110316 Hydroxyapatite is the main component of human bone tissue and is used in modern medicine in the fields of bone tissue engineering, surgery, and dentistry [1]. It demonstrates high biocompatibility, capacity for biodegradation, and osteoinductive and osteoconductive properties [2]. Work is underway to create biocompatible implants that can conduct current, since electrical impulses can stimulate the formation of bone tissue. However, hydroxyapatite does not have the necessary characteristics, and it is necessary to develop methods for its modification. To obtain materials with specified electrical properties, the initial matrix is doped with 3d-element ions, usually by precipitation; copper, nickel, cobalt, and chromium ions with a maximum concentration of 10% are used as dopants; changes in the lattice parameters and the biocompatibility of doping products are discussed [3]. In addition to the nature and concentration of the dopant, the functional properties of the product can be influenced by the morphological parameters of nanoparticles: their size and shape and the size of crystallites, however, information about such works is absent from the literature. Of the above-mentioned series of dopants, the most peculiar is cobalt, as its doping products are intensely colored (which indirectly points to significant changes in the band structure and
electrical properties) [4] and are biocompatible [5]. To create scaffolds based on hydroxyapatite for bone tissue engineering, heat treatment of nanoparticles at temperatures above 900°C is widely used [6] in order to obtain macroporous materials. Doping can significantly change the regions of the thermal stability of materials, so the study of their thermal properties is an urgent task. We obtained cobalt-doped hydroxyapatite nanoparticles with various morphological parameters and studied their influence on the thermal properties. To control these parameters, bases of different strengths (weak NH3∙H2O and strong NaOH) and also mild (precipitation at 100°C) and harsh (hydrothermal synthesis at 180°C) synthesis conditions can be used [7]. Solutions of calcium and cobalt nitrates, orthophosphoric acid, and the appropriate base were used as initial reagents. The reagents were mixed, the pH of
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