Synthesis, Spectral Characterisation and Biological Activities of Novel Biomaterial/N, N, O Donor Tridentate Co (II), Ni
- PDF / 2,811,482 Bytes
- 15 Pages / 595.276 x 790.866 pts Page_size
- 85 Downloads / 172 Views
Synthesis, Spectral Characterisation and Biological Activities of Novel Biomaterial/N, N, O Donor Tridentate Co (II), Ni (II) and Zn (II) Complexes of Hydrazide Based Biopolymer Schiff Base Ligand Murugaiyan Manimohan1 · Sivashanmugam Pugalmani2 · Mohamed Aboobucker Sithique1 Received: 18 March 2020 / Revised: 1 May 2020 / Accepted: 4 May 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract In this study novel biopolymer and water soluble O-carboxymethyl chitosan Schiff base derivatives have been designed for potential use in biological applications. Chemically modified O-carboxymethyl chitosan Schiff base and their metal complexes were prepared for potential application in antibacterial, antifungal, anti-inflammatory, total antioxidant, antidiabetic avenues. Chitosan possess water insolubility has been eliminated by carboxymethylation. The thermal decompositions of metal complexes results that the chitosan polymer had more thermal stability than Schiff base ligand and their Co (II), Ni (II) and Zn (II) metal complexes. The antibacterial results showed that the Ni (II) metal complexes had more efficacies against the bacteria and fungi. The anti-inflammatory studies of compounds reveals that the nickel (II) complex was denatured about 91.88 ± 3.1% of bovine serum albumin (BSA). The biological studies proved that the synthesized compounds possess better antibacterial, antifungal, anti-inflammatory, antidiabetic and antioxidant in nature. Graphic Abstract
Keywords Thermal decomposition · Crystallinity · Chemical modification · Anti-inflammatory · Total antioxidant Extended author information available on the last page of the article
13
Vol.:(0123456789)
1 Introduction Chitin (CN) is the water insoluble linear biopolymer and second most common organic polysaccharide next to cellulose [1]. CN shows several properties such as bacteriostatic action, film forming ability, hydrophobic nature etc. and these make it a well-known biomaterial [2]. CN are employed in various biological and industrial applications which include wound dressing, food packaging and cosmetics. CN contains N-Acetylated glucosamine, (1-4)-linked 2-acetamido-2-deoxy-β-d-glucan [3]. Chitosan (CS) is a linear biopolymer consisting β-(1-4) N-glucosamine. It is obtained from chitin by deacetylation. CS is biodegradable, biocompatible, non-toxic, eco-friendly Biopolymer which helps to reinforce its activity in in-vitro anticancer application [4]. CS is a cationic polysaccharide and its physicochemical and biological properties facilitate several applications [5]. Chitosan derivatives are prepared by various substitution processes viz. phosphorylation, acetylation, enzymation, complexation, quaternization, sulfonation, nitration and carboxymethylation. Besides the polymer can be modified via various chemical modifications mainly, alkylation, hydroxylation, thiolation and graft copolymerization. CS acts as a well-known antimicrobial agent at low pH, due to the presence of positively charged amine units which interact wi
Data Loading...
