Synthesis, characterization and antibacterial activities of nickel(II) and copper(II) complexes of an N-pendent cyanoeth
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ORIGINAL ARTICLE
Synthesis, characterization and antibacterial activities of nickel(II) and copper(II) complexes of an N‑pendent cyanoethyl derivative of a tetraazamacrocycle Ratul Kumar Shil1 · Saswata Rabi1 · Shawon Barua2 · Ruhul Amin2 · Md. Abul Manchur3 · Tapashi Ghosh Roy2 Received: 9 August 2020 / Accepted: 7 October 2020 © Springer Nature B.V. 2020
Abstract An octamethyl substituted tetraazacylotetradecadiene ligand salt Me8[14]diene.2HClO4 (L.2HClO4) on reduction produced three isomeric C-chiral ligands LA, LB & LC. Interaction of LB with excess acrylonitrile resulted in a N-pendent cyanoethyl derivative ligand, LBX. Reaction of LBX with nickel(II) salt, Ni(CH3COO)2.4H2O followed by the addition of NaClO4 afforded the complex, [NiLB](ClO4)2, as resulted by the interaction with LB instead of LBX with the same nickel(II) salt which on twelve hours reflux with acrylonitrile yielded square planar nickel(II) diperchlorate complex, [NiLBX](ClO4)2, This complex underwent axial addition reactions with KX (X = SCN, Br or I) and N aNO2 to form octahedral diisothiocyanatonickel(II) complex, [ NiLBX(NCS)2]; dibromidonickel(II) complex, [ NiLBXBr2]; diiodidonickel(II) complex, [NiLBXI2] and monoaquamononitronickel(II) perchlorate complex, [NiLBX(NO2)(H2O)](ClO4) respectively. The ligand, LBX with copper(II) chloride yielded purple dichloridocopper(II) complex, [ CuLBXCl2] of octahedral geometry which underwent axial substitution reactions with KX and NaNO2 to form octahedral diisothiocyanatocopper(II) complex [CuLBX(NCS)2]; dibromidocopper(II) complex [ CuLBXBr2]; diiodidocopper(II) complex, [ CuLBXI2] and dinitrocopper(II) complex [CuLBX(NO2)2] respectively. These complexes were characterized on the basis of elemental, spectroscopic, magnetochemical and conductrometric analysis. The antibacterial activities of the ligand and complexes have been investigated against different human pathogenic gram positive and gram negative bacteria. Keywords Isomeric tetraazamacrocyclic ligand · N-pendent cyanoethyl derivative · Nickel(II) and copper(II) complexes · Spectroscopic studies · Antibacterial activities
Introduction The synthesis of complexes of transition metals with polyazamacrocyclic ligands is an engrossing area of research because of occupying a major role in the enhancement of coordination chemistry [1]. In recent years host guest chemistry of polyazamacrocyclic ligands with metal ions has been * Tapashi Ghosh Roy [email protected] 1
Department of Chemistry, Chittagong University of Engineering & Technology, Chattogram 4349, Bangladesh
2
Department of Chemistry, University of Chittagong, Chattogram 4331, Bangladesh
3
Department of Microbiology, University of Chittagong, Chattogram 4331, Bangladesh
enhanced rapidly and makes an impression on vast area of both chemistry and biochemistry [2]. Different macrocyclic complexes have been reported to exhibit antitumor activity [3–5]. A broad spectrum of biological activities such as antibacterial [6], antifungal [6] and antivira
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