Systemic Corticosteroids for Inflammatory Disorders in Pediatrics
This comprehensive volume provides the current state of the art use of corticosteroids in the pediatric age group. The book consists of 14 chapters written by leading authors from around the world. The first chapters deal with historical notes, general co
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Systemic Corticosteroids for Inflammatory Disorders in Pediatrics
Systemic Corticosteroids for Inflammatory Disorders in Pediatrics
Rolando Cimaz Editor
Systemic Corticosteroids for Inflammatory Disorders in Pediatrics
Adis
Editor Rolando Cimaz AOU Meyer Pediatric Rheumatology Firenze Italy
ISBN 978-3-319-16055-9 ISBN 978-3-319-16056-6 DOI 10.1007/978-3-319-16056-6
(eBook)
Library of Congress Control Number: 2015941518 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Adis is a brand of Springer Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Contents
Systemic Corticosteroids for Autoimmune/Inflammatory Disorders in Children: Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Giuseppe Saggese and Francesco Vierucci
1
Corticosteroids in the Treatment of Childhood Rheumatic Diseases: A Historical Review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ross E. Petty
11
Systemic Corticosteroids for Autoimmune/Inflammatory Disorders in Children: Clinical Aspects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Pascal Pillet
19
The Molecular and Cellular Mechanisms Responsible for the Anti-inflammatory and Immunosuppressive Effects of Glucocorticoids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Giuseppe Nocentini, Graziella Migliorati, and Carlo Riccardi The Clinical Pharmacology of Past, Present, and Future Glucocorticoids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Giuseppe Nocentini, Simona Ronchetti, Stefano Bruscoli, and Carlo Riccardi
25
43
Corticosteroids in Juvenile Idiopathic Arthritis . . . . . . . . . . . . . . . . . . . . . María M. Katsicas and Ricardo A.G. Russo
59
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