Systems Medicine
This volume guides readers through the field of systems medicine by defining the terminology, and describing how established computational methods form bioinformatics and systems biology can be taken forward to an integrative systems medicine approach.&nb
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Ulf Schmitz Olaf Wolkenhauer Editors
Systems Medicine
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M.Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Systems Medicine Edited by
Ulf Schmitz Department of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany
Olaf Wolkenhauer Department of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany
Editors Ulf Schmitz Department of Systems Biology & Bioinformatics University of Rostock Rostock, Germany
Olaf Wolkenhauer Department of Systems Biology & Bioinformatics University of Rostock Rostock, Germany
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3282-5 ISBN 978-1-4939-3283-2 (eBook) DOI 10.1007/978-1-4939-3283-2 Library of Congress Control Number: 2015956342 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface It is now more than a decade ago since systems biology was celebrated as a new promising approach that can predict the behavior of cellular systems through mathematical modeling and simulation. It was the hope of many that, once systems biology helped deciphering mechanisms underlying disease emergence and progression, it is only a short path toward the design of novel, more successful therapeutic approaches. Although technological advancements allow the generation of ever more detailed snapshots of life across multiple levels of temporal and spatial scales, and despite a wealth of new insights on how life is organized, it is a long way before we are able to translate this improved understanding to achieve a sustainable impact on clinical practice.
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