SZDB2.0: an updated comprehensive resource for schizophrenia research
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ORIGINAL INVESTIGATION
SZDB2.0: an updated comprehensive resource for schizophrenia research Yong Wu1,2 · Xiaoyan Li1,2 · Jiewei Liu1 · Xiong‑Jian Luo1,2,3,5 · Yong‑Gang Yao1,2,4,5 Received: 1 March 2020 / Accepted: 25 April 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract During the past decade, genetic studies of schizophrenia have become one of the most exciting and fast-moving areas. Hundreds of genes implicated in schizophrenia have been identified by genetic, epigenetic, and gene expression studies. However, how to systematically and efficiently use these published data to pinpoint the causal genes becomes a major challenge in schizophrenia research. Here, we release an updated version of a comprehensive database for schizophrenia research, SZDB2.0 (www.szdb.org), which accompanies significant data expansion and feature improvements, as well as functionality optimization. Compared with the first version (SZDB), the current database has the following updates: (1) We added the newly published genome-wide association study (GWAS) of schizophrenia from CLOZUK + PGC, which is the largest GWAS for schizophrenia; (2) We included a polygenic risk score calculator; (3) In the refined “Gene” module of SZDB2.0, we collated genetic, gene expression, methylation, and integrative results of all available schizophrenia studies; (4) In the “CNV (copy number variation)” module, we collated the results of all 77 CNV publications about schizophrenia; (5) We also updated other data, including gene expression quantitative trait loci (eQTL), transcript QTL, methylation QTL, and protein–protein interaction data, based on the information from the latest literatures. We optimized the query interface of SZDB2.0 for a better visualization and data retrieval. The updated SZDB2.0 will advance the research of schizophrenia.
Introduction
* Xiong‑Jian Luo [email protected] * Yong‑Gang Yao [email protected] 1
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China
2
Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, Yunnan, China
3
Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
4
CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
5
KIZ‑CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China
Schizophrenia is a complex, heterogeneous behavioral and cognitive syndrome with a heritability as high as to 80%, almost the highest in all psychiatric disorders (Sullivan et al. 2012; Sullivan and Geschwind 2019). Genetics and gene expression studies of schizophrenia have been accumulated over 2 decades, how to efficiently use these published data to elucidate the genetic basi
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