T cell responses against tumor associated antigens and prognosis in colorectal cancer patients
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T cell responses against tumor associated antigens and prognosis in colorectal cancer patients Dirk Nagorsen*1, Carmen Scheibenbogen1, Anne Letsch1, ChristophThomas Germer2, Heinz-Johannes Buhr2, Susanna Hegewisch-Becker3, Licia Rivoltini4, Eckhard Thiel1 and Ulrich Keilholz1 Address: 1Medical Department III, Hematology, Oncology, and Transfusion Medicine, Charité University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany, 2Department of Surgery, Charité University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany, 3Department of Oncology and Hematology, University Clinic Eppendorf, Hamburg, Germany and 4Istituto Nazionale Tumori, Milan, Italy Email: Dirk Nagorsen* - [email protected]; Carmen Scheibenbogen - [email protected]; Anne Letsch - [email protected]; Christoph-Thomas Germer - [email protected]; HeinzJohannes Buhr - [email protected]; Susanna Hegewisch-Becker - [email protected]; Licia Rivoltini - [email protected]; Eckhard Thiel - [email protected]; Ulrich Keilholz - [email protected] * Corresponding author
Published: 19 January 2005 Journal of Translational Medicine 2005, 3:3
doi:10.1186/1479-5876-3-3
Received: 22 November 2004 Accepted: 19 January 2005
This article is available from: http://www.translational-medicine.com/content/3/1/3 © 2005 Nagorsen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
T cell responseantigencolorectal cancersurvivalprognosis
Abstract Introduction: Spontaneous T cell responses against specific tumor-associated antigens (TAA) are frequently detected in peripheral blood of tumor patients of various histiotypes. However, little is known about whether these circulating, spontaneously occurring, TAA-reactive T cells influence the clinical course of disease. Methods: Fifty-four HLA-A2 positive colorectal cancer patients had been analyzed for the presence of T cell responses against epitopes derived from the TAA Ep-CAM, her-2/neu, and CEA either by ELISPOT assay or by intracellular cytokine staining. Then, Kaplan-Meier survival analysis was performed comparing T-cell-responders and T-cell-non-responders. For comparison, a group of T-cell-non-responders was compiled stringently matched to T-cell-responders based on clinical criteria and also analyzed for survival. Results: Sixteen out of 54 patients had a detectable T cell response against at least one of the three tested TAA. Two out of 21 patients (9.5%) with limited stage of disease (UICC I and II) and 14 out of 33 patients (42.4%) with advanced disease (UICC III and IV) were T cell response positive. Comparing all T-cell-responders (n = 16) and all T-cell-non-responders (n = 38), no survival difference was found. In an att
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