T Lymphocytes as Tools in Diagnostics and Immunotoxicology
This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharma
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Stefan F. Martin Editor
T Lymphocytes as Tools in Diagnostics and Immunotoxicology
Experientia Supplementum Volume 104
For further volumes: http://www.springer.com/series/4822
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Stefan F. Martin Editor
T Lymphocytes as Tools in Diagnostics and Immunotoxicology
Editor Stefan F. Martin Department of Dermatology and Venereology University Medical Center Freiburg Freiburg Germany
ISSN 1023-294X ISBN 978-3-0348-0725-8 ISBN 978-3-0348-0726-5 (eBook) DOI 10.1007/978-3-0348-0726-5 Springer Basel Heidelberg New York Dordrecht London Library of Congress Control Number: 2013954368 © Springer Basel 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer Basel is part of Springer Science + Business Media (www.springer.com)
Contents
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The Use of T Cells in Hazard Characterization of Chemical and Drug Allergens and Integration in Testing Strategies . . . . . . . Ian Kimber and Marc Pallardy Activation of the TCR Complex by Peptide-MHC and Superantigens . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Christine Louis-Dit-Sully, Britta Blumenthal, Marlena Duchniewicz, Katharina Beck-Garcia, Gina J. Fiala, Esmeralda Beck-Garcı´a, Markus Mukenhirn, Susana Minguet, and Wolfgang W.A. Schamel
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Activation of the TCR Complex by Small Chemical Compounds . . . . Christine L
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