T1 mapping, T2 mapping and MR elastography of the liver for detection and staging of liver fibrosis
- PDF / 913,838 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 17 Downloads / 219 Views
HEPATOBILIARY
T1 mapping, T2 mapping and MR elastography of the liver for detection and staging of liver fibrosis David H. Hoffman1 · Abimbola Ayoola1 · Dominik Nickel2 · Fei Han2 · Hersh Chandarana1 · Krishna Prasad Shanbhogue1
© Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Purpose To compare liver stiffness measurements obtained from MR elastography with liver T1 relaxation times obtained from T1 mapping and T2 relaxation times obtained from T2 mapping for detection and staging of liver fibrosis. Materials and methods 223 patients with known or suspected liver disease underwent MRI of the liver with T1 mapping (Look-Locker sequence) and 2D SE-EPI MR elastography (MRE) sequences. 139 of these patients also underwent T2 mapping with radial T2 TSE sequence. Two readers (R1 & R2) measured liver stiffness, T1 relaxation times and T2 relaxation times. T1 and T2 times were correlated with stiffness measurements. ROC analysis was used to compare the performance of both techniques in discriminating fibrosis stage in 23 patients who underwent liver biopsy. Results For each reader there was significant moderate positive correlation between liver MRE and liver T1 mapping (r = 0.49 and 0.36). There was significant moderate positive correlation between liver T2 mapping and each of MRE and T1 mapping for one of the readers (r = 0.40 and 0.27). AUC for differentiating early (F0–F2) from advanced (F3–F4) fibrosis in biopsied patients was 0.975 (R1) and 0.925 (R2) for MRE, 0.671 (R1) and 0.642 (R2) for T1 mapping and 0.671 (R1) and 0.743 (R2) for T2 mapping. Inter-reader agreement was good for MRE (ICC = 0.84) substantial for T1 mapping (0.94) and T2 mapping (0.96). Conclusions Liver T1 and T2 mapping showed moderate positive correlation with MR elastography. Accuracy of MRE is however superior to T1 and T2 mapping in the subset of patients who underwent liver biopsy. Accuracy of combination of MRE and T1 mapping/T2 mapping was not superior to MRE alone. Keywords Liver fibrosis · MR elastography (MRE) · T1 mapping · T2 mapping
Introduction * Krishna Prasad Shanbhogue [email protected] David H. Hoffman [email protected] Abimbola Ayoola [email protected] Dominik Nickel marcel.nickel@siemens‑healthineers.com Fei Han fei.han@siemens‑healthineers.com Hersh Chandarana [email protected] 1
Department of Radiology, NYU Langone Health, 660 First Ave, New York, NY 10016, USA
Siemens Healthcare GmbH, Erlangen, Germany
2
Chronic liver disease is increasing in prevalence worldwide, with an estimated prevalence of nearly 25% for nonalcoholic fatty liver disease [1]. With obesity and diabetes increasing in many parts of the globe, the World Gastroenterology Organization has estimated that the prevalence of non-alcoholic fatty liver disease has doubled in the last two decades. Hepatic fibrosis is considered the liver’s wound-healing response to a variety of insults [2]. The liver attempts to isolate continued injury by scar formation, similar to
Data Loading...
