Hepatic magnetic resonance T1-mapping and extracellular volume fraction compared to shear-wave elastography in pediatric
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ORIGINAL ARTICLE
Hepatic magnetic resonance T1-mapping and extracellular volume fraction compared to shear-wave elastography in pediatric Fontan-associated liver disease Charlotte de Lange 1,2 & Karl Julius Thrane 1 & Kristian S. Thomassen 1 & Oliver Geier 3 & Bac Nguyen 1 & Anders Tomterstad 1 & Lil-Sofie Ording Müller 1 & Erik Thaulow 4,5 & Runar Almaas 6 & Gaute Døhlen 4 & Kathrine Rydén Suther 1 & Thomas Möller 4 Received: 11 February 2020 / Revised: 10 June 2020 / Accepted: 10 August 2020 # The Author(s) 2020
Abstract Background Children with Fontan circulation are at risk of developing hepatic fibrosis/cirrhosis. Reliable noninvasive monitoring techniques are lacking or under development. Objective To investigate surrogate indicators of hepatic fibrosis in adolescents with Fontan circulation by evaluating hepatic magnetic resonance (MR) T1 mapping and extracellular volume fraction measurements compared to US shear-wave elastography. Materials and methods We analyzed hepatic native T1 times and extracellular volume fractions with modified Look-Locker inversion recovery. Liver stiffness was analyzed with shear-wave elastography. We compared results between 45 pediatric patients ages 16.7±0.6 years with Fontan circulation and 15 healthy controls ages 19.2±1.2 years. Measurements were correlated to clinical and hemodynamic data from cardiac catheterization. Results MR mapping was successful in 35/45 patients, revealing higher hepatic T1 times (774±44 ms) than in controls (632 ±52 ms; P
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