Tadalafil
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Tadalafil Leucocytoclastic vasculitis: case report
A 65-year-old man developed leucocytoclastic vasculitis during treatment with tadalafil for erectile dysfunction. The case was reported to the Spanish health authorities (Centro de Farmacovigilancia de la Comunidad de Madrid). The man presented with a 2-day history of non-pruritic palpable purpuric rash of the lower extremities without arthralgias, fever or malaise. Medical history revealed he had a erectile dysfunction, for which, he had taken tadalafil [Cialis; route not stated] 20mg, 2 days before the presentation, as prescribed by his urologist. He had taken tadalafil for the first time. His other medications included solifenacin and lorazepam. Blood examinations were normal for haemogram, coagulation, basic biochemistry and immunology. Urinalysis showed neither hematuria nor proteinuria. Cutaneous biopsy of the eruption demonstrated a leucocytoclastic vasculitis. He did not have a history of transfusion, hepatitis, inflammatory bowel disease, recent travels, lupus erythematosus, rheumatoid arthritis, Sjogren syndrome or any active infection as a possible causes of leucocytoclastic vasculitis. The man’s treatment with tadalafil was discontinued. After 45 days, his condition improved and the skin lesions disappeared. A diagnosis of tadalafil-induced leucocytoclastic vasculitis was made. Aguilar-Shea AL, et al. Tadalafil and Purpura. Journal of Sexual Medicine 6: 1787-1788, No. 6, Jun 2009. Available from: URL: http://doi.org/10.1111/ j.1743-6109.2009.01234.x
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Reactions 14 Nov 2020 No. 1830
