Targeted Drugs for Cancer Therapy: Small Molecules and Monoclonal Antibodies
Specific targeting of tumor cells without inflicting collateral damage on normal healthy cells has been, and remains, a long-standing aim in cancer therapy. Effective targeting of tumor cells without accompanying toxicity has started to be realized with t
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Drug Allergy
Brian A. Baldo • Nghia H. Pham
Drug Allergy Clinical Aspects, Diagnosis, Mechanisms, Structure-Activity Relationships Second Edition
Brian A. Baldo, AUA(Pharmacy), BSc(Hons), PhD (Retired) Formerly: Royal North Shore Hospital of Sydney Head, Molecular Immunology Unit Kolling Institute of Medical Research and University of Sydney Sydney, NSW Australia
Nghia H. Pham, MSc, PhD (Retired) Formerly: Royal North Shore Hospital of Sydney Molecular Immunology Unit Kolling Institute of Medical Research and University of Sydney Sydney, NSW Australia
ISBN 978-3-030-51739-7 ISBN 978-3-030-51740-3 (eBook) https://doi.org/10.1007/978-3-030-51740-3 © Springer Nature Switzerland AG 2021 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Dedicated to the memories of my mother, Sylvia, and my father, Disma, for their care, guidance and enduring support and whose values, hard work, self-reliance, and plain commonsense instructed by example –Brian A. Baldo Dedicated to the memories of my parents with love and gratitude and to Phong-Thuy and Cecile for their love, support, and encouragement –Nghia H. Pham
Preface to 2nd Edition
In the first edition of this book, we drew attention to the under-appreciation throughout the medical disciplines of the problems of drug allergy, manifesting in many different forms from transient minor itch and erythema to life- threatening responses such as anaphylaxis and severe bullous eruptions. At the time, it was acknowledged that substantial progress in diagnosis, treatment, prevention, and understanding mechanisms of drug reactions is dependent on increased knowledge of the intricate cellular immune processes involved in antigen recognition, cell r
