Targeted Therapy of Colorectal Cancer Subtypes
In this book, a group of researchers shares their expertise on the identification and characterization of genetic colorectal cancer subtypes. They describe solid pathobiological knowledge on the distinct sporadic tumour subtypes, including the mutations f
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Peter Jordan Editor
Targeted Therapy of Colorectal Cancer Subtypes
Advances in Experimental Medicine and Biology Volume 1110
Editorial Board IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy NIMA REZAEI, Tehran University of Medical Sciences, Children’s Medical Center Hospital, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Peter Jordan Editor
Targeted Therapy of Colorectal Cancer Subtypes
Editor Peter Jordan Department of Human Genetics National Health Institute ‘Dr. Ricardo Jorge’ Lisbon, Portugal BioISI – Biosystems & Integrative Sciences Institute, Faculty of Sciences University of Lisbon Lisbon, Portugal
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-030-02770-4 ISBN 978-3-030-02771-1 (eBook) https://doi.org/10.1007/978-3-030-02771-1 Library of Congress Control Number: 2018966511 © Springer Nature Switzerland AG 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
1 Colorectal Cancer Subtypes – The Current Portrait������������������ 1 Peter Jordan 2 Targeting Colon Cancers with Mutated BRAF and Microsatellite Instability�������������������������������������������������������� 7 Paulo Matos and Peter Jordan 3 Targeting KRAS Mutant CMS3 Subtype by Metabolic Inhibitors ���������������������������������������������������������������� 23 Oscar Aguilera and Roberto Serna-Blasco 4 Targeting the PI3K Signalling as a Therapeutic Strategy in Colorectal
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