Molecularly Targeted Therapy for Childhood Cancer
Molecularly-Targeted Therapy for Childhood Cancer is a comprehensive exploration of the molecular aspects of childhood cancers that are currently being targeted therapeutically or are in the early phases of development. Each chapter describes key molecula
- PDF / 9,252,953 Bytes
- 548 Pages / 439.37 x 666.142 pts Page_size
- 4 Downloads / 244 Views
w
Peter J. Houghton Robert J. Arceci ●
Editors
Molecularly Targeted Therapy for Childhood Cancer
Editors Peter J. Houghton Elizabeth M. and Richard M. Ross Chair Director, Center for Childhood Cancer The Research Institute Nationwide Children’s Hospital 700 Children’s Drive Columbus, OH 43205 [email protected]
Robert J. Arceci King Fahd Professor of Pediatric Oncology Professor of Pediatrics Oncology and Cellular and Molecular Medicine Kimmel Comprehensive Cancer Center at Johns Hopkins The Bunting and Blaustein Cancer Research Building 1650 Orleans Street, Suite 207 Baltimore, MD 21231 USA [email protected]
ISBN 978-0-387-69060-5 e-ISBN 978-0-387-69062-9 DOI 10.1007/978-0-387-69062-9 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010930693 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Acknowledgments
We would like to especially thank all the authors and investigators who contributed to the content of this book along with the publisher for believing in the importance of directly addressing important issues concerning children with cancer.
v
w
Contents
Part I Hematologic Malignancies The Emerging Era of Targeted Therapy in Childhood Acute Lymphoblastic Leukemia..................................................................... William L. Carroll and Rob Pieters
3
Molecular Targeted Therapies in T-CellAcute Lymphoblastic Leukemia................................................................................ Alejandro Gutierrez and A. Thomas Look
19
Molecularly Targeted Therapy for Infant ALL............................................ Patrick A. Brown and Carolyn A. Felix
31
Targeted Therapeutic Approaches for AML................................................. Robert J. Arceci and Donald Small
59
Acute Promyelocytic Leukaemia.................................................................... Andrea Biondi, Anna Maria Testi, and Brenda E.S. Gibson
83
Down Syndrome and Acute Myeloid Leukemia: An Unique Genetic Sensitivity to Chemotherapy......................................... 109 Jeffrey W. Taub, Yubin Ge, and Yaddanapudi Ravindranath Targeting RAS Signaling Pathways in Juvenile Myelomonocytic Leukemia (JMML)......
Data Loading...
