Tectochrysin increases stress resistance and extends the lifespan of Caenorhabditis elegans via FOXO/DAF-16
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RESEARCH ARTICLE
Tectochrysin increases stress resistance and extends the lifespan of Caenorhabditis elegans via FOXO/DAF-16 Min Lu . Lin Tan . Xiao-Gang Zhou . Zhong-Lin Yang . Qing Zhu . Jian-Ning Chen . Huai-Rong Luo . Gui-Sheng Wu
Received: 12 February 2020 / Accepted: 23 May 2020 Ó Springer Nature B.V. 2020
Abstract Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Tectochrysin is a flavonoid compound and rich in a traditional Chinese Medicine Alpinia oxyphylla Miq., which has antioxidant, antiinflammatory, anti-cancer, anti-bacterial, anti-diarrhea, hepatoprotective, and neuro-protective effects. Therefore, we tested if tectochrysin had an effect on aging in Caenorhabditis elegans (C. elegans). Our results showed that tectochrysin could extend the lifespan of C. elegans by up to 21.0%, delay the agerelated decline of body movement, improve high temperature-stress resistance and anti-infection Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10522-020-09884-w) contains supplementary material, which is available to authorized users. M. Lu L. Tan X.-G. Zhou Z.-L. Yang Q. Zhu J.-N. Chen H.-R. Luo (&) G.-S. Wu (&) Key Laboratory for Aging and Regenerative Medicine, Department of Pharmacology School of Pharmacy, Southwest Medical University, 319 Zhongshan Road, Luzhou 646000, Sichuan, China e-mail: [email protected] G.-S. Wu e-mail: [email protected] H.-R. Luo G.-S. Wu Key Laboratory of Medical Electrophysiology, Ministry of Education, Institute of Cardiovascular Research of Southwest Medical University, Luzhou 646000, Sichuan, China
capacity, and protected worms against Ab1-42-induced toxicity. Tectochrysin could not extend the lifespan of the mutants from genes daf-2, daf-16, eat2, aak-2, skn-1, and hsf-1. Tectochrysin could increase the expression of DAF-16 regulated genes. The extension of lifespan by tectochrysin requires FOXO/DAF-16 and HSF-1. Overall, our findings suggest that tectochrysin may have a potential effect on extending lifespan and age-related diseases. Keywords Tectochrysin Aging FOXO/DAF-16 Age-related diseases Caenorhabditis elegans
Introduction Aging is a natural phenomenon that occurs in -most living organisms. In humans, aging is associated with lowered overall functioning and increased risk for various age-related diseases (Castillo-Quan et al. 2015). Hence, researchers are keen on finding effective components that can promote healthy aging and extend lifespan. The natural decline of function occurring with aging could be prevented and / or reversed through various ways such as gene modifications, dietary interventions, and hormetic mechanism (Kunugi and Mohammed Ali 2019). Accumulating evidence indicated that traditional herbs could promote healthy aging and lengthen
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Biogerontology
healthy lifespans, such as Ginseng Radix et Rhizoma (Biswas et al. 2017), the extract of Aralia chinensis L (Zhang et al. 20
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