Temperature-responsive hydroxypropyl methylcellulose- N -isopropylacrylamide aerogels for drug delivery systems
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ORIGINAL RESEARCH
Temperature-responsive hydroxypropyl methylcellulose-Nisopropylacrylamide aerogels for drug delivery systems Zhongming Liu . Sufeng Zhang . Bin He . Shoujuan Wang . Fangong Kong
Received: 10 May 2020 / Accepted: 29 August 2020 Ó Springer Nature B.V. 2020
Abstract Temperature-responsive aerogels from hydroxypropyl methylcellulose (HPMC)-grafted N-isopropylacrylamide (NIPAM) were developed for the first time as a novel drug delivery system. The morphology and structure of temperature-responsive HPMC-NIPAM aerogels were characterized with scanning electron microscopy, Fourier-transform infrared, X-ray diffraction, and X-ray photoelectron spectroscopic analyses. Water-soluble 5-fluorouracil was used as a model drug to study drug loading and release. Drug release experiments demonstrated a sustained and controlled release behavior of the HPMC-NIPAM aerogels that were highly dependent on temperature. Meanwhile, the first-order kinetic
Z. Liu S. Zhang (&) B. He F. Kong (&) Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, National Demonstration Center for Experimental Light Chemistry Engineering Education, Key Laboratory of Paper Based Functional Materials of China National Light Industry, Shaanxi University of Science and Technology, Xian 710021, China e-mail: [email protected] F. Kong e-mail: [email protected] Z. Liu S. Wang F. Kong State Key Laboratory of Biobased Material and Green Papermaking, Key Laboratory of Pulp and Paper Science & Technology of Ministry of Education/Shandong Province, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China
model, Higuchi model, and Korsmyer–Peppas model were used to fit the sustained-release curve of drugloaded aerogel revealing a sustained-release mechanism. Keywords Temperature-responsive HPMCNIPAM aerogels Drug-loaded aerogel Drug release
Introduction Drug delivery systems have received increasing attention due to their relatively steady release rate, reduced toxicity, and optimized drug therapy (Fazil et al. 2015; Saini et al. 2020). The carriers for drug release can affect the release profile, drug loading capacity, and bioavailability, and they have been the subject of much multidisciplinary research. In addition to the form of drug carriers, the development of substrate materials has also become a frequent topic in drug release research (Li et al. 2019). Biopolymers can offer controlled release of drugs due to their good biocompatibility and degradability. Cellulose, chitosan, starch, and sodium alginate have been widely reported for controlled drug release (Hu et al. 2015; Huo et al. 2016; Plappert et al. 2019). Hydroxypropyl methylcellulose (HPMC) is an important derivative of cellulose that is often used to prepare oral controlled drug delivery systems (Ha-
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Cellulose
Lien Tran et al. 2020; Siepmann and Peppas 2012). One of the most important characteristics of HPMC is their good swelling properties, whi
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